孟鲁司特联合布地奈德治疗小儿咳嗽变异性哮喘的临床疗效分析  

Analysis of the Clinical Efficacy of Montelukast Combined with Budesonide in the Treatment of Cough Variant Asthma in Children

作　　者：王磊 WANG Lei(Liaoning Jinzhou Women and Infants Hospital,Jinzhou 121000,China)

机构地区：[1]辽宁省锦州市妇婴医院,辽宁锦州121000

出　　处：《中国医药指南》2020年第18期114-115,共2页Guide of China Medicine

摘　　要：目的关于孟鲁司特联合布地奈德对小儿咳嗽变异性哮喘治疗的效果评价。方法本文所选择的研究对象均来自我院在2017年6月至2018年11月收治的小儿咳嗽变异性哮喘患儿,将68例患儿按照随机方法分为常规治疗组和联合治疗组,平均每组34例,对两组患儿均选择采用常规基础治疗方案进行治疗,常规治疗组选择孟鲁斯特钠进行治疗,联合治疗组在常规基础上为患儿配合布地奈德进行治疗评价并比较两组患儿治疗的效果。结果经过治疗后对两组患儿临床症状进行评价,常规治疗组的咳嗽消失时间、肺部哮鸣音消失时间分别为(8.5±1.5)d、(11.4±2.3)d,联合治疗组则分别为(3.8±0.7)d、(5.5±0.4)d,两组比较,P<0.05,差异存在统计学意义;本文常规治疗组的治疗总有效率为73.53%(25/34),联合治疗组治疗总有效率94.12%(32/34),P<0.05,差异存在统计学意义;常规治疗组不良反应发生率为17.65%(6/34),联合治疗组为20.59%(7/34),P>0.05,两组无差异,不具有统计学意义。结论对小儿咳嗽变异性哮喘在治疗的过程中,为患儿选择采用孟鲁司特联合布地奈德进行治疗能够有效改善患儿的临床治疗效果,促进患儿症状的缓解,并且不会产生严重的不良反应,值得推广应用。Objective To evaluate the effi cacy of montelukast combined with budesonide in the treatment of cough variant asthma in children.Methods In this paper,the research subjects are chosen from our hospital in June 2017 to November 2018 children with infantile cough variant asthma,68 cases in accordance with the method of random divided into conventional treatment group and combination group,every group of 34 cases,the two groups of children with all choose the conventional foundation treatment,treatment of conventional treatment group choose meng sodium rust treatment,combined treatment group on the basis of routine treatment for children with budesonide to evaluate and compare the treatment effect in two groups of children.Results After treatment,the clinical symptoms of the two groups were evaluated.The disappearance time of cough and asthma in the conventional treatment group was(8.5±1.5)d,(11.4±2.3)d,and the disappearance time of asthma in the combined treatment group was(3.8±0.7)d,(5.5±0.4)d,respectively.In this study,the total effective rate of the conventional treatment group was 73.53%(25/34),and the total effective rate of the combined treatment group was 94.12%(32/34),P<0.05,and the difference was statistically signifi cant.The incidence of adverse reactions was 17.65%(6/34)in the conventional treatment group and 20.59%(7/34)in the combined treatment group,with P>0.05.There was no signifi cant difference between the two groups.Conclusion In the course of treatment for children with cough variant asthma,the combination of montelukast and budesonide can effectively improve the clinical treatment effect of children,promote the relief of symptoms,and produce no serious adverse reactions,which is worthy of promotion and application.

关 键 词：孟鲁斯特 布地奈德 小儿咳嗽变异性哮喘 

分 类 号：R725.6[医药卫生—儿科] R562.25[医药卫生—临床医学]