甲巯咪唑与丙硫氧嘧啶治疗甲亢的临床价值  

The Clinical Value of Methimazole and Propylthiouracil in the Treatment of Hyperthyroidism

作　　者：魏宪丰 WEI Xian-feng(Department of Endocrinology,Panshan County People's Hospital,Panjin 124100,China)

机构地区：[1]辽宁省盘锦市盘山县人民医院内分泌科,辽宁盘锦124100

出　　处：《中国医药指南》2020年第18期126-127,共2页Guide of China Medicine

摘　　要：目的对比研究甲状腺功能亢进患者采用甲疏咪唑与丙硫氧嘧啶两种药物进行治疗的临床效果。方法选择以往在我院接受药物治疗的102例甲状腺功能亢进患者,通过随机分组的方式分成对照组(51例)和治疗组(51例)。对照组采用丙硫氧嘧啶进行治疗;治疗组采用甲疏咪唑进行治疗。结果治疗组患者甲状腺功能亢进药物治疗总有效率达到90.2%,高于对照组的68.6%;仅有3例药物不良反应,少于对照组的9例;甲状腺功能恢复正常时间和药物治疗总时间短于对照组;治疗前后甲状腺功能相关指标、心理状态相关指标、生活质量评分的改善效果优于对照组;对临床用药方案的满意度达到94.1%,高于对照组的80.4%。组间数据比较差异有统计学意义(P<0.05)。结论甲状腺功能亢进患者采用甲疏咪唑进行治疗,可以减少药物不良反应,大幅度改善甲状腺功能和生活质量,使患者保持良好心态,从而缩短病情恢复和治疗时间,使治疗效果和患者满意度得到同步提升。Objective To compare the clinical effects of methimazole and propylthiouracil in the treatment of hyperthyroidism.Methods 102 patients with hyperthyroidism who had been treated with drugs in our hospital were randomly divided into control group(51 cases)and treatment group(51 cases).The control group was treated with propylthiouracil and the treatment group was treated with methimazole.Results The total effective rate of hyperthyroidism drug treatment in the treatment group was 90.2%,higher than 68.6%in the control group;only 3 cases had adverse drug reactions,less than 9 cases in the control group;the total time of thyroid function recovery and drug treatment was shorter than that in the control group;the improvement effect of thyroid function related indicators,psychological status related indicators and quality of life score before and after treatment was better than that in the control group.In the control group,the satisfaction rate of clinical medication was 94.1%,which was higher than 80.4%in the control group.There were signifi cant differences in data between groups(P<0.05).Conclusion Mesomidazole can reduce adverse drug reactions,improve thyroid function and quality of life,keep patients in a good state of mind,shorten the recovery and treatment time,and improve the therapeutic effect and patients'satisfaction simultaneously in patients with hyperthyroidism.

关 键 词：甲状腺功能亢进 甲疏咪唑 丙硫氧嘧啶 甲状腺功能 

分 类 号：R581.1[医药卫生—内分泌]