抗痨颗粒辅助抗结核药物对患者非结核分枝杆菌性肺病的疗效及其对T细胞亚群的影响  

Efficacy of Kanglao Granules Combined with Anti-TB Drugs in Patients with Non-TB Mycobacterial Lungs Disease and Its Influence on T cell

作　　者：时翠林[1,2] 虞忻[1,2] 沈洁[1,2] 叶志坚 吴妹英[1,2] SHI Cui-lin;YU Xin;SHEN Jie;YE Zhi-jian;WU Mei-ying(The Infectious Diseases Hospital Affiliated to Suzhou University,Suzhou Jiangsu 215013,China;Department of Pulmonary Medicine,The No.5 PeoPle's Hospital of Suzhou,Suzhou Jiangsu 215013,China)

机构地区：[1]苏州大学附属传染病医院,江苏苏州215013 [2]苏州市第五人民医院肺科,江苏苏州215013

出　　处：《抗感染药学》2020年第5期730-733,共4页Anti-infection Pharmacy

基　　金：苏州市科技局指导性项目吴门医派课题(编号:SYSD2018193);苏州市科技发展计划(民生科技)项目(编号:SYS2019111)。

摘　　要：目的:探究抗痨颗粒辅助抗结核药物对非结核分枝杆菌性肺病的临床疗效及其对T细胞亚群改善的影响。方法:选取2017年1月—12月期间诊治的非结核分枝杆菌性肺病患者70例资料,按治疗用药的不同将其分为治疗组和对照组,每组35例;其中对照组患者给予抗结核分枝杆菌药物治疗,治疗组患者在对照组基础上加用中药抗痨颗粒治疗;观察两组患者用药治疗前和治疗3月的临床疗效(分枝杆菌转阴率、CT影像学好转率)、临床症状评分值以及T细胞亚群各指标的变化情况。结果:治疗组患者治疗后的中医症状(咳嗽咳痰、盗汗、食欲症状改善情况)评分值均低于对照组(P<0.01);两组患者治疗前CD4、CD8、CD4/CD25测得值经组间比较其差异均无统计学意义(P>0.05);治疗组患者治疗后CD4测得值优于对照组(P<0.01);而CD8、CD4/CD25测得值两组间无统计学意义(P>0.05)。结论:采用抗痨颗粒辅助抗结核药物治疗非结核分枝杆菌性肺病患者,有效改善了CD4水平,其机制可能与调节CD4 T细胞水平有关。Objective:To explore the clinical efficacy of Kanglao granules assisted by anti-tuberculosis drugs on non-tuberculous Mycobacterial(NTM)lungs disease and its improvement on T cell subsets.Methods:Data of 70 patients with NTM lung disease diagnosed and treated from January to December 2017 were selected and divided into treatment group and control group according to different treatment and medication,with 35 cases in each group.The patients in the control group were treated with antituberculous Mycobacteria,and the patients in the treatment group were treated with the traditional Chinese medicine(TCM)Kanglao granules on the basis of the control group.The clinical effects(Mycobacterial negative rate,CT imaging improvement rate),clinical symptom scores,and changes of T cell subsets of the two groups of patients before and after treatment were observed.Results:The scores of TCM symptoms(night sweat,appetite)in the treatment group were lower than those in the control group(P<0.05).After treatment,the CD4 in the two groups was significantly higher than before treatment(P<0.05),and the CD4 value in the treatment group was significantly higher than that in the control group(P<0.001).But CD8,CD4/CD25 regulatory T cell%were not statistically significant between the two groups before and after treatment(P>0.05).Conclusion:Kanglao granules were used to assist antituberculosis drugs in patients with NTM tuberculosis,which effectively improved CD4 level,and the mechanism may be related to the regulation of CD4 T cell level.

关 键 词：非结核分枝杆菌 抗痨颗粒 抗结核药 CD4值 

分 类 号：R563.1[医药卫生—呼吸系统]