狂犬病疫苗与人狂犬病免疫球蛋白联用对动物咬伤患者预防狂犬病的发生及其对抗体产生的影响  

Efficacy of Rabies Vaccine Combined with HRIG on Prevention of Rabies in Animal Bite Patients and Its Influence on Antibody Production

作　　者：李雪梅[1] LI Xue-mei(The No.1 People's Hospital of Xinxiang,Xinxiang He'ncm 453000,China)

机构地区：[1]新乡市第一人民医院,河南新乡453000

出　　处：《抗感染药学》2020年第5期734-737,共4页Anti-infection Pharmacy

摘　　要：目的:探究狂犬病疫苗与人狂犬病免疫球蛋白(HRIG)联用对动物咬伤患者预防狂犬病发生效果及其对抗体产生的影响。方法:选取2019年7月—10月间治疗的因动物咬伤暴露患者200例资料,按预防用药的不同将其分为两组,狂犬疫苗接种组(n=100,单用接种狂犬病疫苗)和联用组(n=100,接种狂犬病疫苗与HRIG联用),比较两组患者抗狂犬病抗体阳性率和不良反应发生率的差异。结果:用药7 d后,联用组患者狂犬病抗体阳性率优于狂犬疫苗接种组(P<0.05);治疗14 d后,两组患者狂犬病抗体阳性率经组间比较其差异无统计学意义(P>0.05),不良反应发生率之间也无统计学意义(P>0.05)。结论:狂犬病疫苗与HRIG联用于动物咬伤暴露患者预防狂犬病的临床疗效更佳,短时间内人体可有效产生狂犬病抗体,且安全性高。Objective:To explore the efficacy of rabies vaccine combined with human rabies immunoglobulin(HRIG)on the prevention of rabies in animal bite patients and its influence on antibody production.Methods:Data of 200 patients with animal bite exposure treated from July to October 2019 were selected.Based on the different prophylactic drugs,patients were divided into two groups,the rabies vaccination group(n=100,only with the inoculation of rabies vaccine)and the combined use group(n=100,rabies vaccine and HRIG combined use).The difference between the positive rate of anti-rabies antibody and the incidence of adverse drug reactions were compared between the two groups.Results:After 7 days of administration,the positive rate of rabies antibody in the combined treatment group was better than that in the rabies vaccination group(P<0.05).After 14 days of treatment,there were no statistically significant difference in the positive rate of rabies antibody between the two groups(P>0.05),and there were no statistically significant difference in the incidence of adverse drug reactions(P>0.05).Conclusion:Rabies vaccine combined with HRIG has better clinical efficacy in preventing rabies in patients exposed to animal bite.The human body can effectively produce rabies antibody in a short time,and the safety is high.

关 键 词：狂犬病疫苗 人狂犬病免疫球蛋白 狂犬病 

分 类 号：R969.4[医药卫生—药理学]