微波促进I2催化吲哚3-硒氰酸化制备3-硒氰酸吲哚衍生物  

Microwave-Assisted Iodine-Catalyzed 3-Selenocyanation of Indole for the Synthesis of 3-Selenocyanateindole Derivatives

作　　者：吴燕 田仙芝 张海玲 陈睿 曹团武[1] Wu Yan;Tian Xianzhi;Zhang Hailing;Chen Rui;Cao Tuanwu(Chongqing Key Laboratory of Inorganic Special Functional Materials,College of Chemistry and Chemical Engineering,Yangtze Normal University,Fuling 408000)

机构地区：[1]长江师范学院化学化工学院无机特种材料重庆市重点实验室,涪陵408000

出　　处：《有机化学》2020年第5期1384-1387,共4页Chinese Journal of Organic Chemistry

基　　金：重庆市基础前沿研究(Nos.Cstc2018jcyjAX0721,Cstc2016jcyjA0056);长江师范学院青年人才成长计划(No.2018QNRC11);重庆市教育委员会(No.KJQN201801404)资助项目.

摘　　要：3-硒氰酸吲哚衍生物由于良好的生物活性,在药物研究方面具有潜在的应用价值.目前,关于3-硒氰酸吲哚的制备方法存在一定的不足,如反应条件苛刻、产率较低、底物适用性较差等.采用微波促进I2催化吲哚与硒氰酸钾的反应,制备了一系列3-硒氰酸吲哚衍生物.与已有方法相比,本方法具有反应速率快、产率高、原子经济性好等优点,为3-硒氰酸吲哚衍生物的制备提供高效的路径.3-Selenocyanateindole derivatives have potential application in drug research due to their good biological activity.Until now,many methods for the synthesis of 3-selenocyanateindoles have been reported.However,drawbacks still exist,such as harsh reaction conditions,low yields and poor functional groups tolerance.A series of 3-selenocyanateindoles have been synthesized via the microwave-assisted 3-selenocyanation of indole derivatives by using 25 mol%iodine as catalyst,affording the corresponding products in good yields.Compared with the previous methods,this protocol has the advantages of rapid reaction,high yields and good atomic economy,providing an efficient route to 3-selenocyanateindole derivatives.

关 键 词：微波辅助反应 碘催化硒氰酸化 3-硒氰酸吲哚 吲哚衍生物 硒氰酸钾 

分 类 号：O626.13[理学—有机化学]