一种1,1-二氯烯烃化合物的新合成方法  

Method for the Synthesis of 1,1-Dichloroalkenes

作　　者：任新锋[2] 宋小平[1] 马影超 李亚 Ren Xinfeng;Song Xiaoping;Ma Yingchao;Li Ya(Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education,Hainan Normal University,Haikou 570100;College of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620)

机构地区：[1]海南师范大学省部共建-热带药用植物化学教育部重点实验室,海口570100 [2]上海工程技术大学化学化工学院,上海201620

出　　处：《有机化学》2020年第5期1388-1393,共6页Chinese Journal of Organic Chemistry

基　　金：海南师范大学省部共建-热带药用植物化学教育部重点实验室开放基金(No.2013-6)资助项目.

摘　　要：1,1-二氯烯烃结构存在于许多天然产物中,同时也是一类重要的合成中间体,广泛应用于炔烃、卤代炔烃以及芳烃化合物的合成.报道了一个新的1,1-二氯烯烃化试剂:二氯甲基(2-吡啶基)砜.以叔丁醇钾作为碱,二氯甲基(2-吡啶基)砜与芳香醛顺利反应,以良好的产率制备得到了1,1-二氯烯烃化合物.该方法实验操作简便、试剂易得且纯化方便.The 1,1-dichloroalkene structural unit is found in many natural products.1,1-Dichloroalkenes are important intermediates,which have been widely used in the synthesis of alkynes,halogenated acetylenes and aromatic compounds.In this paper,a new dichloroolefinating reagent,dichloromethyl 2-pyridyl sulfone,was reported.1,1-Dichloroalkenes can be conveniently obtained from the reaction of dichloromethyl 2-pyridyl sulfone with aromatic aldehydes using t-BuOK as base.This method has the advantage of operational simplicity,usage of easily available reagents and easy purification,which may find applications in organic synthesis.

关 键 词：二氯甲基砜 1 1-二氯烯烃 芳香醛 

分 类 号：O623.22[理学—有机化学]