双酚A暴露与学龄女童代谢综合征发生的相关性研究  

Correlation between bisphenol A exposure and metabolic syndrome in school-age girls

作　　者：赵金华[1] 洪菲[1] 陆生丽[1] 周峰[2] 徐明[1] ZHAO Jin-hua;HONG Fei;LU Sheng-li;ZHOU Feng;XU Ming(Department of Paediatrics,the First People′s Hospital of Nantong City,Nantong,Jiangsu 226001,China;Department of Laboratory,the First People′s Hospital of Nantong City,Nantong,Jiangsu 226001,China)

机构地区：[1]南通市第一人民医院儿科,江苏南通226001 [2]南通市第一人民医院检验科,江苏南通226001

出　　处：《中国儿童保健杂志》2020年第6期633-636,共4页Chinese Journal of Child Health Care

基　　金：南通市卫生局项目(YYZ16018)。

摘　　要：目的探讨双酚A(BPA)暴露与学龄女童代谢综合征(MetS)发生的相关性。方法于2016年9月-2017年9月随机抽取314名小学(来自崇川区、港闸区、通州区)在校女童,收集其尿液样本,开展BPA浓度检测。按BPA检出结果分为BPA暴露组和BPA非暴露组。同时测量两组儿童的体格状况,测体重指数(BMI),收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、空腹胰岛素(FIS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)。比较两组各检测指标间差异,以及各代谢指标与其BPA暴露之间的关系。结果学龄女童BPA暴露组232名,BPA非暴露组82名,BPA检出率为73.89%。BPA暴露组女童BMI、SBP、FBG、FIS、TG、TC高于BPA非暴露组(P<0.05),BPA暴露组女童HDL-C则低于BPA非暴露组(P<0.05)。共有58名女童超重及肥胖,发生率为18.47%,其中BPA暴露组49名,BPA非暴露组9名。超重及肥胖女童在BPA暴露组与非暴露组中发生率有统计学意义(χ~2=4.14,P<0.05)。有8个女童符合MetS标准,均为BPA暴露组女童。结论 BPA暴露情况在学龄女童中普遍存在。BPA暴露女童更易发生超重和肥胖。MetS定义中各指标在BPA暴露女童中均高于BPA非暴露女童,提示在学龄女童中BPA暴露与其发生MetS存在一定的关联,BPA暴露可能是MetS发生的危险因素之一。Objective To investigate the correlation between bisphenol A(BPA)exposure and metabolic syndrome in school-age girls.Methods From September 2016to September 2017,314primary school students were randomly selected from Chongchuan District,Gangzha District and Tongzhou District to collect urine samples and conduct BPA concentration testing.According to the results of BPA detection,the participants were divided into BPA exposure group and BPA non-ex-posure group.At the same time,the physical condition of the two groups of children,including body mass index(BMI),sys-tolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),fasting insulin(FIS),triglyceride(TG),total cholesterol(TC)and high-density lipoprotein cholesterol(HDL-C),were measured and evaluated.The differ-ences of each indicator between the two groups and the relationship between each metabolic index and BPA exposure were analyzed.Results Among school-age girls,there were 232girls in the BPA exposure group and 82girls in the BPA non-exposure group.The detection rate of BPA was 73.89%.The BMI,SBP,FBG,FIS,TG,and TC of the BPA exposure group were higher than those of the BPA non-expoure group(P<0.05).The HDL-C of the BPA exposwre group was lower than that of the BPA non-exposure group(P<0.05).There were 58girls(49girls in the BPA exposure group,9girls in the non-exposure group)who were overweight and obese,and the detection rate of overweight and obesity was 18.47%.The inci-dence of overweight and obese girls in the BPA exposure and non-exposure groups was significantly different(χ2=4.14,P<0.05).Eight girls met the criteria for metabolic syndrome,all in the BPA exposure group.Conclusion Bisphenol A exposure is prevalent in school-age girls.Girls exposed to BPA are more likely to be overweight and obese.In children with metabolic syndrome,the indicators were higher in BPA-exposed girls than in BPA-non-exposed girls,suggesting that there is a correlation between BPA exposure and metabolic syndrome in school-age girls,and exposure to BPA

关 键 词：双酚A 代谢综合征 学龄女童 

分 类 号：R725.8[医药卫生—儿科]