分枝杆菌感染相关儿童原发性免疫缺陷病  

Primary immunodeficiency diseases susceptible to mycobacteria in children

作　　者：尹青琴[1] 贺建新[1] 徐保平[1] Yin Qingqin;He Jianxin;Xu Baoping(National Clinical Research Center for Respiratory Diseases,Department of Respiratory,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院呼吸科,国家呼吸系统疾病临床医学研究中心,北京100045

出　　处：《中华实用儿科临床杂志》2020年第10期779-782,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：北京市医院管理中心儿科学科协同发展中心专项经费(XTZD20180104)。

摘　　要：原发性免疫缺陷病(PIDs)是一类由单基因突变引起免疫细胞或免疫分子缺陷,最终导致免疫功能降低、缺如或免疫调节功能失衡的疾病。PIDs患儿更易发生感染性疾病,由于不同病原菌感染宿主的免疫机制有所差异,不同类型的PIDs相对易感的病原学种类也不尽相同。目前多项研究指出,某些PIDs患儿更易发生卡介苗感染、重症结核病及非结核分枝杆菌重症感染。现就与分枝杆菌易感密切相关的主要PIDs进行概述,包括慢性肉芽肿病、严重联合免疫缺陷病、孟德尔遗传易感分枝杆菌病及高IgM综合征等,以期为临床医师早期识别此病提供理论基础。Primary immunodeficiency diseases(PIDs)refer to immune function decrease and deficiency or immune regulation function imbalance resulted from immune cell or immunomolecular defects caused by single gene mutation.Children with PIDs are prone to develop infectious diseases.Because the immune mechanisms of hosts infected by different pathogens infecting vary,different types of PIDs are relatively susceptible to different pathogens.A number of studies have indicated that some PIDs children are more likely to develop Bacilles Calmétte-Guerin infection,severe tuberculosis and non-Tuberculous mycobacteria severe infection.In this review,several major primary immunodeficiency diseases closely related to the susceptibility of mycobacteria were summarized,including chronic granulomatous disease,severe combined immunodeficiency disease,mendelian susceptibility to mycobacterial disease,and high IgM syndrome,in order to provide a theoretical basis for early identification of such diseases.

关 键 词：原发性免疫缺陷病 分枝杆菌 结核分枝杆菌 儿童 

分 类 号：R725.9[医药卫生—儿科]