妊娠期女性人乳头瘤病毒感染分型及其对产后并发症和新生儿近期状况的影响  

Genotyping analysis of human papillomavirus infection in pregnant women and its influences on postpartum complications and neonatal recent situations

作　　者：金海红[1] 赖筱琍[1] 余军辉[1] JIN Hai-hong;LAI Xiao-li;YU Jun-hui(Department of Obstetrics and Gynecology,Taizhou Hospital of Zhejiang Province,Taizhou,Zhejiang 317000,China)

机构地区：[1]浙江省台州医院,浙江台州317000

出　　处：《中国病毒病杂志》2020年第2期137-141,共5页Chinese Journal of Viral Diseases

摘　　要：目的研究妊娠期女性人乳头瘤病毒(HPV)感染分型情况,分析其对产后并发症和新生儿近期的影响。方法选取2017年3月-2018年3月在浙江省台州医院产检并确诊为HPV感染的妊娠期女性及其新生儿各194例为研究对象,另取同期在该院产检无HPV感染的妊娠期女性及其新生儿各87例为对照组。通过聚合酶链反应技术检测HPV病毒在妊娠期女性及新生儿中的表达情况并检测HPV分型,分析HPV感染分型对产后并发症和新生儿近期状况的影响。结果妊娠期女性HPV感染高危型占总HPV感染患者的78.35%(152/194),低危型占21.65%(42/194)。高危型HPV感染组、低危型HPV感染组、对照组妊娠期妇女产褥感染发生率(分别为18.42%,2.38%和2.30%)和新生儿呼吸窘迫综合征发生率(分别为21.05%,7.14%和3.45%)比较,差异有统计学意义(χ^2分别为18.418和16.382,P均<0.05)。新生儿HPV感染率占总新生儿的40.21%(78/194),其中高危型占总新生儿HPV感染者的87.18%(68/78),低危型占12.82%(10/78);45例新生儿与孕妇HPV感染类型一致,33例新生儿不一致。高危型HPV感染组新生儿脐静脉血HPV阳性率显著高于低危型HPV感染组(69.12%vs 30.00%,χ^2=5.797,P<0.05)。结论妊娠期女性HPV感染以高危型较多,高危型HPV感染与产妇产褥感染发生率、新生儿呼吸窘迫综合征发生率及新生儿脐静脉血HPV阳性率有关。Objective To study the genotypes of human papillomavirus(HPV)among infected pregnant women,and to analyze its influences on postpartum complications and neonatal recent situations.Methods From March 2017to March 2018,194pregnant women with prenatal examination diagnosed with HPV infection in Taizhou Hospital and their newborns were recruited as the study subjects,and 87pregnant women without HPV infection and their newborns in this hospital during the same period were selected as the control group.The expression of HPV and HPV genotyping in pregnant women and newborns was detected by polymerase chain reaction.Results The high-risk type of HPV infection in pregnant women was 78.35%(152/194)of the total HPV infections while low-risk was 21.65%(42/194).The incidence of puerperal infection and neonatal respiratory distress syndrome in high-risk HPV infection group,low-risk HPV infection group and control group were significantly different(incidence of puerperal infection:18.42%vs 2.38%vs 2.30%;incidence of neonatal respiratory distress syndrome:21.05%vs 7.14%vs 6.90%),P<0.05.The infection rate of HPV in newborns was 40.21%(78/194)with the high-risk type accounted for 87.18%(68/78)while the low-risk type accounted for 12.82%(10/78).HPV infection types of 45newborns were consistent with that of the pregnant women while 33were not.The positive rate of HPV in umbilical vein blood of highrisk HPV infection group was significantly higher than that of low-risk group(69.12%vs 30.00%,χ^2=5.797,P<0.05).Conclusions HPV infection in pregnant women is likely at high-risk.High-risk HPV infection is related to the incidence of puerperal infection,the incidence of neonatal respiratory distress syndrome and the positive rate of HPV in neonatal umbilical vein blood.

关 键 词：妊娠 人乳头瘤病毒 感染分型 产后并发症 新生儿 新生儿近期状况 

分 类 号：R373.9[医药卫生—病原生物学]