深圳地区15例早期2019新型冠状病毒感染的临床特征  

Clinical Characteristics of 15 Cases of Early 2019 Novel Coronavirus Infection in Shenzhen

作　　者：于恪 徐学敏[1] 施睿[1] 高波[1] 武莉莉[1] 黄河[1] 邓海燕[1] 张敏[1] YU Ke;XU Xue-min;SHI Rui;GAO Bo;WU Li-li;HUANG He;DENG Hai-yan;ZHANG Min(Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,Guangdong Shenzhen 518035)

机构地区：[1]深圳市第二人民医院深圳大学第一附属医院,广东深圳518035

出　　处：《深圳中西医结合杂志》2020年第8期7-11,共5页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:分析深圳地区早期2019新型冠状病毒(2019-nCoV)感染的流行病学及临床特征。方法:回顾性分析深圳市第二人民医院2020年1月20日至2020年2月7日连续确诊的早期2019-nCoV感染的15例患者的流行病学特征、症状、实验室检查及影像学特征。结果:(1)流行病学及基线特征:15例感染者的年龄30~73岁,平均(50.7±14.7)岁,女性患者多于男性;93.3%的患者有武汉旅居史或密切接触过武汉返深人员,均无华南海鲜市场接触史;40.0%患者有慢性基础病及免疫力低下病史;(2)临床表现:发热为最常见占86.7%,大部分为中低热。其次为咳嗽症状,流涕较少见占26.7%,腹泻患者3例(20.0%);(3)实验室检查:93.3%的患者白细胞正常,未发现白细胞减低;淋巴细胞计数减少占53.3%;50.0%的患者超敏C反应蛋白(hs-CRP)及38.5%的降钙素原(PCT)增高,且绝大部分为轻度增高;(4)影像学表现:肺部病变以单侧病变为主,双侧病变仅占45.5%,90.9%病变为磨玻璃影。1例为实变影患者,随访肺部影像进展同时伴淋巴细胞动态降低。(5)临床亚型分析:普通型为主,占73.7%,轻型患者症状至确诊时间短于普通型。结论:深圳地区早期2019-nCoV感染流行病学与临床特征与武汉地区存在共性,但也存在着一定的区域差异。动态监测淋巴细胞计数变化对病情评估存在着一定的价值。Objective To analyze the epidemiological and clinical characteristics of early 2019 novel coronavirus(2019-nCoV)infection in Shenzhen.Methods A retrospective analysis of the epidemiological characteristics,symptoms,laboratory tests and imaging characteristics of 15 patients with early 2019-nCoV infection diagnosed continuously from January 20,2019 to February 7,2020 in Shenzhen second people's hospital.Results(1)Epidemiological and baseline characteristics:15 infected patients aged 30-73 years,with an average of 50.7±14.7 years,and more female patients than males;93.3%of the patients had a history of staying in Wuhan or people who had been in close contact with Wuhan returning to Shenzhen,and had no history of exposure to the Huanan seafood wholesale market;40.0%Of patients have a history of chronic underlying diseases and low immunity;(2)Clinical manifestations:Fever is the most common,accounting for 86.7%,and most of them are moderate to low fever.Followed by cough symptoms,catarrhal symptoms of upper respiratory tract infections were less common(26.7%),and 3 patients with diarrhea(20.0%);(3)Laboratory tests:93.3%of patients had normal white blood cells,and no white blood cell reduction was found;lymphocyte counts decreased accounted for 53.3%;50.0%of patients had increased high-sensitivity C-reactive protein(hs-CRP)and 38.5%procalcitonin(PCT),and most of them were mildly elevated;(4)Imaging findings:Lung lesions were treated with a single The lesions were mainly lateral,with bilateral lesions accounting for only 45.5%,and 90.9%lesions were ground glass.One patient was a consolidation patient.Follow-up of lung imaging was accompanied by a decrease in lymphocyte dynamics.(5)Analysis of clinical subtypes:The common type is the main type,accounting for 73.7%,and the time from diagnosis to diagnosis of the mild patient is shorter than that of the common type.Conclusion The epidemiological and clinical characteristics of early 2019-nCoV infection in Shenzhen are similar to those in Wuhan,but there are some regional

关 键 词：2019新型冠状病毒 新型冠状病毒肺炎 淋巴细胞计数 胸部CT 

分 类 号：R563.1[医药卫生—呼吸系统] R181.8[医药卫生—内科学]