OCT参数评价兔颈动脉粥样硬化斑块性质的实验研究  

Evaluation of carotid atherosclerotic plaques in rabbits by OCT parameters

作　　者：许振坤[1] 任丽玮 原涛 王献忠[1] XU Zhenkun;REN Liwei;YUAN Tao;WANG Xianzhong(The Second Department of Cardiology,the First Hospital of Handan City,Hebei Handan 056902,China)

机构地区：[1]邯郸市第一医院心内二科,河北邯郸056902

出　　处：《新疆医科大学学报》2020年第6期722-727,共6页Journal of Xinjiang Medical University

基　　金：邯郸市科学技术局资助项目(1723208066-10)。

摘　　要：目的分析光学相干断层成像(optical coherence tomography,OCT)参数对兔颈动脉粥样硬化斑块性质的评价价值。方法取28只新西兰大白兔分为3组。高脂组予以高脂饲养,球囊损伤+高脂组予以球囊拉伤+高脂饲养,对照组予以标准饲料。结果干预后球囊损伤+高脂组、高脂组干预后甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白-胆固醇(low density lipoprotein-cholesterol,LDL-C)均升高(P<0.05),且均高于对照组P<0.05),高密度脂蛋白-胆固醇(high density lipoprotein-cholesterol,HDL-C)均下降(P<0.05),且均低于对照组(P<0.05);球囊损伤+高脂组明显小于其余2组(P<0.05),且高脂组明显小于对照组(P<0.05);球囊损伤+高脂组纤维帽厚度薄于高脂组(P<0.05),管腔偏心指数、脂质池角度均高于高脂组(P<0.05);球囊损伤+高脂组可见典型颈动脉粥样硬化病变和斑块形成特征,高脂组有轻微特征;球囊损伤+高脂组、高脂组和3组(球囊损伤+高脂组、高脂组、对照组)中不稳定斑块纤维帽厚度均薄于稳定斑块(P<0.05),脂质池角度均大于稳定斑块(P<0.05);OCT检查评价斑块性质与病理结果的一致性均较高。结论球囊损伤+高脂饲养、单纯高脂饲养均可诱导兔颈动脉粥样硬化斑块形成,OCT参数可见明显异常,与病理结果的一致性较高。Objective To analyze on the value of optical coherence tomography(OCT)parameters in evaluating the properties of carotid atherosclerotic plaques in rabbits.Methods Twenty-eight New Zealand white rabbits were randomly divided into 3 groups.The hyperlipidemia group was fed with high-fat diet alone.Balloon injury+hyperlipidemia group was given balloon injury plus hyperlipidemia feeding.The control group was fed with standard feed.Results The levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C)increased after balloon injury+hyperlipidemia group and hyperlipidemia group intervention(P<0.05),which were higher than those in the control group(P<0.05);and high density lipoprotein cholesterol(HDL-C)decreased(P<0.05),which was lower than that in the control group(P<0.05).The balloon injury+hyperlipidemia group was significantly smaller than the other two groups(P<0.05),and the hyperlipidemia group was significantly smaller than the control group(P<0.05).The thickness of fibrous cap in the balloon injury+hyperlipidemia group was thinner than that in the hyperlipidemia group(P<0.05),and the lumen eccentricity index and the angle of lipid pool were higher than those in the hyperlipidemia group(P<0.05).Typical carotid atherosclerotic lesions and plaque formation were observed in the balloon injury+hyperlipidemia group,and mild changes were in the hyperlipidemia group.The fibrous cap thicknesses of unstable plaques in the balloon injury+hyperlipidemia group,hyperlipidemia group and three groups(balloon injury+highfat,hyperlipidemia,the contnd group)were thinner than those of stable plaques(P<0.05),and the angles of lipid pool were larger than those of stable plaques(P<0.05).The consistencies of OCT in evaluating plaque properties and pathological results were higher.Conclusion The formation of atherosclerotic plaque can be induced by balloon injury+high-fat feeding and high-fat feeding alone.OCT parameters are obviously abnormal,which is highly consistent with the pathological results.

关 键 词：光学相干断层成像 颈动脉粥样硬化 斑块性质 

分 类 号：R543.5[医药卫生—心血管疾病]