妊娠期高血压患者血常规指标变化及其与炎性标记物的相关性研究  

Changes of hematologic parameters and their correlation with inflammatory markers in patients with hypertension during pregnancy

作　　者：潘亚静 邓文秋 PAN Yajing;DENG Wenqiu(Department of Gynecology and Obstetrics,Guigang Hospital of Traditional Chinese Medicine,Guigang Guangxi 537100,China;Department of Gynecology and Obstetrics,Qintang District People's Hospital,Guigang Guangxi,537121,China)

机构地区：[1]贵港市中医医院妇产科,广西贵港537100 [2]贵港市覃塘区人民医院妇产科,广西贵港537121

出　　处：《新疆医科大学学报》2020年第6期768-772,共5页Journal of Xinjiang Medical University

基　　金：贵港市科学研究与计划开发项目(贵科攻1701016)。

摘　　要：目的考察妊娠期高血压疾病(hypertensive disorders of pregnancy,HDP)患者的血液学指标特征及其与炎性细胞因子之间的关系。方法研究组(HDP组)由2018年2月-2019年4月在贵港市中医医院确诊为HDP的76例孕妇组成,包括14例妊娠期高血压、44例先兆子痫和18例子痫患者。另招募77例正常妊娠女性作为对照组(即正常妊娠组)。检测两组受试者的血液学参数和白细胞介素-6(interleukin 6,IL-6)、IL-10和肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)。比较两组受试者上述指标的组间差异,考察血液学参数与炎性细胞因子间的相关性。结果与正常妊娠组女性相比,HDP组患者白细胞计数、中性粒细胞计数、红细胞分布宽度(RDW)、IL-6和IL-10均升高,差异有统计学意义(P<0.001);HDP组患者血红蛋白水平、血小板计数、嗜酸性粒细胞计数均低于正常妊娠组女性,差异有统计学意义(P<0.001)。IL-6与中性粒细胞、单核细胞之间存在显著正相关,与血红蛋白、嗜酸性粒细胞、血小板计数、红细胞压积之间存在显著负相关(P<0.05)。IL-10与嗜酸性粒细胞、TNF-α与血红蛋白之间均存在较弱的负相关(P<0.05)。结论HDP患者的血液学参数、细胞因子发生显著变化,且部分血液学参数与细胞因子之间有一定的相关性,说明妊娠期HDP患者存在炎症反应和免疫应答的失衡。血液学联合炎性细胞因子的检测,在临床医疗和护理中对HDP的发生和发展具有一定的预测价值。Objective To investigate the characteristics of hematologic parameters and their relationship with inflammatory cytokines in patients with hypertensive disorders of pregnancy(HDP).Methods A total of 76 pregnant women diagnosed with HDP in our hospital from February 2018 to April 2019 were investigated,including 14 cases of gestational hypertension,44 cases of preeclampsia and 18 cases of epilepsy.Another 77 normal pregnant women were recruited as control group.Hematological parameters,interleukin 6(IL-6),IL-10 and Tumor Necrosis factor-alpha(TNF-α)of the two groups were tested.The differences between the two groups were compared to investigate the correlation between the hematological parameters and the inflammatory cytokines.Results As compared with women in the normal pregnancy group,the white blood cell count,neutrophil count,erythrocyte distribution width(RDW),IL-6 and IL-10 showed significant differences(P<0.001).The hemoglobin level,platelet count and eosinophil count in the HDP group were lower than those in the normal pregnancy group,with statistically significant differences(P<0.001).There was a significant positive correlation between IL-6 and neutrophils and monocytes,and a significant negative correlation between IL-6 and hemoglobin,eosinophils,platelet counts and hematocrit(P<0.05).There was a weak negative correlation between IL-10 and eosinophils,TNF-αand hemoglobin(P<0.05).Conclusion The hematological parameters and cytokines of HDP patients were significantly changed,and some hematological parameters were correlated with the cytokines,which are suggested that there is an imbalance in inflammatory response and immune response in patients with HDP.The detection of hematology combined with the inflammatory cytokines can provide certain predictive value for the occurrence and development of HDP.

关 键 词：妊娠期高血压疾病 血液学 炎症标记物 围产期 

分 类 号：R714.252[医药卫生—妇产科学]