2018年甘肃省10岁以下儿童流感病毒和呼吸道合胞病毒感染特征  

Analysis of influenza and respiratory syncytial virus infection characteristics in children under 10 years of age in Gansu province in 2018

作　　者：于德山[1] 傅生芳 徐丛杉 马超 张慧[1] 王婉 陈建华[1] 唐悦 李保娣[1] 赵忆宁 李红育[1] 关文竹 王健 Yu Deshan;Fu Shengfang;Xu Congshan;Ma Chao;Zhang Hui;Wang Wan;Chen Jianhua;Tang Yue;Li Biaodi;Zhao Yining;Li Hongyu;Guan Wenzhu;Wang Jian(Gansu Center for Disease Control and Prevention,Lanzhou 730000,China;China Lanzhou Biological Products Research Institute Co.,Ltd,Gansu Provincial Vaccine Engineering Technology Research Center,Lanzhou 730046,China)

机构地区：[1]甘肃省疾病预防控制中心,甘肃省传染病病原学重点实验室,兰州730000 [2]兰州生物制品研究所有限责任公司,甘肃省疫苗工程技术研究中心,730046

出　　处：《中华实验和临床病毒学杂志》2020年第2期155-159,共5页Chinese Journal of Experimental and Clinical Virology

基　　金：国家"十三五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10103006,2017ZX10104001-005)。

摘　　要：目的为了解甘肃省2018年10岁以下儿童中门诊流感样(influenza-like illnes,ILI)病例中流感病毒(influenza virus,Flu)、呼吸道合胞病毒(respiratory syncytial virus,RSV)的病原学特点及流行特征,为Flu、RSV疾病的诊断治疗及防控提供依据。方法选取甘肃省19家国家级流感监测哨点医院ILI病例咽拭子标本共8559份,用实时荧光PCR检测流感病毒,对其中的3436份,用RT-PCR法对RSV检测。结果Flu阳性934份,阳性率10.91%,其中甲型H1N1阳性431例、H3N2阳性70例、乙型428例、甲型H1N1和乙型混合5例;RSV阳性320份,阳性率9.31%。14个市州之间Flu、RSV检测阳性率差异存在统计学意义(χ^2=56.99,Р<0.01;χ^2=263.34,Р<0.01)。流感1月份为最高峰,阳性率为50.70%,乙型B/Yamagata系(占53.53%)和甲型H1N1(占39.93%)同时流行。RSV的流行高峰在2~4月,阳性率达13.98%,5岁以下儿童RSV阳性率10.11%,高于5岁及以上儿童RSV的阳性率6.94%.具有统计学意义(χ^2=7.67,Р<0.01)。结论10岁以下儿童ILI就诊病例中RSV和Flu是主要的病原,每年冬春季节存在流行高峰,建议加强RSV的监测。Objective To study the epidemic and etiologic characteristics of influenza virus(Flu)and respiratory syncytial virus(RSV)infections in outpatient influenza-like illness(ILI)cases of children under 10 years of age in Gansu province in 2018 And to provide evidences for diagnosis,treatment,control and prevention of Flu and RSV infections in Gansu province.Methods A total of 8559 pharyngeal swab samples of ILI outpatients cases were tested with real-time fluorescent PCR to detect Flu,3436 of which were detected by RT-PCR for RSV.Results Of the 8559 specimens,934(10.91%)samples were positive for Flu.Among them,431 were positive for H1N1,70 were positive for H3N2,428 were positive for Flu B,5 were mixed;320 of the 3436(9.31%,)samples were positive for RSV.There were significant differences in the positive rates of Flu and RSV among 14 cities and prefectures(χ^2=56.99,χ^2=263.34,Р<0.01).Influenza reached its peak in January 2018 with a positive rate of 50.70%.Flu B/Yamagata strain(53.53%)and A H1N1(39.93%)were prevalent simultaneously.The peak of RSV epidemic was from February to April,the positive rate was 13.98%.The RSV positive rate of children under 5 years of age was 10.11%,higher than that of children over 5 years of age was 6.94%.There was statistical significance(χ^2=7.67,Р<0.01).Conclusions RSV and influenza viruses are the main pathogens in ILI cases of children under 10 years of age.There are epidemic peaks in winter and spring every year.It is suggested that the monitoring of RSV and the development and application of vaccine should be strengthened.

关 键 词：呼吸道合胞病毒 流感病毒 儿童 流行病学 

分 类 号：R72[医药卫生—儿科]