美托洛尔致严重水肿  

Severe edema caused by metoprolol

作　　者：刘兰兰 赵娟娟 Liu Lanlan;Zhao Juanjuan(Department of Clinical Pharmacy,Mengyin County People′s Hospital,Shandong Province,Mengyin 276299,China;Department of Cardiovascular Medicine,Mengyin County People′s Hospital,Shandong Province,Mengyin 276299,China)

机构地区：[1]山东省蒙阴县人民医院临床药学科,276299 [2]山东省蒙阴县人民医院心血管内科,276299

出　　处：《药物不良反应杂志》2020年第5期317-318,共2页Adverse Drug Reactions Journal

摘　　要：1例62岁女性患者冠状动脉支架植入术后遵医嘱规律口服阿司匹林肠溶片(100 mg、1次/d)、硫酸氢氯吡格雷片(75 mg、1次/d)、酒石酸美托洛尔片(18.75 mg、2次/d)和瑞舒伐他汀钙片(10 mg、1次/d)。数日后患者出现手脚水肿且逐渐由四肢远端向近端发展,并出现面部水肿,水肿部位出现皮疹伴瘙痒。给予抗过敏治疗3 d,水肿无明显消退且有新发皮疹,经仔细询问得知患者每每在服用酒石酸美托洛尔片后约2 h水肿和皮疹症状加重,试停服酒石酸美托洛尔片1 d,其他药物继续应用。次日患者水肿及皮疹减轻,当日遵医嘱再用该药则上述症状复现。再次停用该药,次日水肿和皮疹即明显好转。停药2 d后患者自行改服琥珀酸美托洛尔缓释片,仍出现水肿和皮疹。停用琥珀酸美托洛尔缓释片,10 d后水肿和皮疹完全消退。A 62-year-old female patient received oral aspirin enteric-coated tablets 100 mg once daily,clopidogrel hydrogen sulphate tables 75 mg once daily,metoprolol tartrate tablets 18.75 mg twice daily,and rosuvastatin calcium tablets 10 mg once daily after coronary artery stent implantation regularly according to the doctor′s instructions.Several days later,the patient developed edema of hands and feet from the distal end to the proximal end of the extremities,and he developed facial edema with rash and pruritus at the edema site.After 3 days of antiallergic treatment,there was no obvious regression of edema and new rash.After careful inquiry,the patient said that he always developed edema and increased rash symptoms about 2 hours after taking metoprolol tartrate tablets.After discontinuation of metoprolol tartrate tablets for 1 day,and other drugs were continued to be used,the patient′s edema and rash were relieved on the next day,and the above symptoms reappeared when the drug was used again according to the doctor′s instructions on the same day.When the drug was stopped again,the edema and rash were obviously improved the next day.After 2 days of discontinuation,the patient took metoprolol succinate sustained-release tablets at their own discretion,and still developed edema and rash.After discontinuation of metoprolol succinate sustained-release tablets,the edema and rash disappeared completely 10 days later.

关 键 词：美托洛尔 水肿 药疹 药物过敏 

分 类 号：R9[医药卫生—药学]