苯并咪唑类驱虫药抗肿瘤作用机制的研究进展  

Research progress on mechanism of antiparasitic medications with benzimidazole structure in treatment of cancer

作　　者：吕金津 王巍[1] Lü Jin-jin;WANG Wei(School of Pharmacy,Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学药学院,湖北武汉430071

出　　处：《现代药物与临床》2020年第5期1045-1048,共4页Drugs & Clinic

基　　金：国家自然科学基金资助项目(21202125)。

摘　　要：近年来的研究报告显示,在细胞水平和体外动物水平上,苯并咪唑类驱虫药物如甲苯咪唑、芬苯达唑具有抑制或辅助抑制癌症的功能,个别患者使用后病程发展得到改善,相关的临床试验已经注册开展研究。主要介绍苯并咪唑类驱虫药甲苯咪唑和芬苯达唑可能具有的抗肿瘤作用机制,包括解聚微管蛋白、抑制葡萄糖的摄取和代谢、影响信号通路、抑制血管生成等途径。Recent studies suggest that antiparasitic medications with benzimidazole structure such as mebendazole and fenbendazole are effective in treatment of cancer,use as single drug or auxiliary drug at the cellular level and animal level in vitro.There are few case reports with objective or complete response.And a series of clinical trials have been proved to study the effectiveness.The possible anti-cancer mechanisms of antiparasitic medications with benzimidazole structure such as mebendazole and fenbendazole,including tubulin depolymerization,inhibition of uptake and metabolism of glucose,inhibition of signal transduction and angiogenesis inhibition are summarized in this paper.

关 键 词：苯并咪唑 甲苯咪唑 芬苯达唑 癌症 作用机制 

分 类 号：R979.1[医药卫生—药品]