Anti-lung Cancer Activity and Docking Study of Two Novel Isochroman Derivatives  

作　　者：LI Di 李迪(Inner Mongolia University for Nationalities,Tongliao 028000,China)

机构地区：[1]Inner Mongolia University for Nationalities,Tongliao 028000,China

出　　处：《Chinese Journal of Structural Chemistry》2020年第5期901-907,共7页结构化学（英文）

基　　金：supported by the Project of Inner Mongolia University for the Nationalities(No.NMDYB15064);Science Research Project of Inner Mongolia Education Department(No.NJZY20114)。

摘　　要：Two new isochroman derivatives(1 and 2)were isolated from the fermentation products of mangrove endophytic fungus Phomopsis sp.33#.Their structures were characterized by IR,~1 H NMR,H RMS,and single-crystal X-ray crystallography.The anticancer activity of the two compounds was investigated against four human lung cancer cells(NCI-H292,NCI-H460,LTEP-A-2 and MSTO-211)by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay.Furthermore,molecular docking studies supported the biological assay data,showing that compared with 1,compound 2 has stronger interaction with protein.

关 键 词：isochroman derivatives anticancer activity MTT assay molecular docking 

分 类 号：TQ460.1[化学工程—制药化工]