肠道菌群经肠-脑轴参与多囊卵巢综合征发病机制的研究进展  

Research progress of gut microbiota involved in the pathogenesis of polycystic ovary syndrome through gut⁃brain axis

作　　者：陈志静 欧燕兰[2] 杨滢 李荔[1] CHEN Zhijing;OU Yanlan;YANG Ying;LI Li(Department of Obstetrics and Gynecology,Guangdong Women and Children Hospital Affiliated to Guangzhou Medical University,Guangzhou 510010,China)

机构地区：[1]广东省妇幼保健院暨广州医科大学附属广东省妇儿医院妇产科,广州510010 [2]广东省妇幼保健院暨广州医科大学附属广东省妇儿医院体检科,广州510010

出　　处：《实用医学杂志》2020年第11期1542-1546,共5页The Journal of Practical Medicine

基　　金：广东省科技发展专项资金(编号:2014A020212237,2017ZC0378);广东省中医药局重点专项(编号:20184005);广州市科技创新委员会(编号:201904010458,201510010290)。

摘　　要：多囊卵巢综合征主要以排卵障碍、高雄激素血症及卵巢多囊样改变为特征的一种内分泌紊乱性疾病。目前关于多囊卵巢综合征的发病机制尚不清楚,但近年的研究发现肠道菌群与多囊卵巢综合征之间存在密切联系,肠道菌群可能经肠-脑轴参与该疾病的发病。本文主要针对近年来肠道菌群在多囊卵巢综合征中的相关研究,对肠-脑轴参与多囊卵巢综合征发病机制进行综述。Polycystic ovary syndrome is an endocrine disorder characterized by ovulation disorders,hyperandrogenemia,and polycystic ovarian changes.At present,the pathogenesis of polycystic ovary syndrome is unclear,but recent studies have found that there is closely associated between the gut microbiota and polycystic ovary syndrome.The gut microbiota may be involved in the pathogenesis of the disease through the gut⁃brain axis.This article focuses on the research of gut microbiota in polycystic ovary syndrome in recent years,and reviews the intestinal⁃brain axis involvement in the pathogenesis of polycystic ovary syndrome.

关 键 词：肠道菌群 多囊卵巢综合征 肠-脑轴 

分 类 号：R711.6[医药卫生—妇产科学]