浅谈ABSL-2实验室运行管理要点  

A Brief Introduction About Key Points of Management in ABSL-2 Laboratory

作　　者：杨华[1] 赵勇 宋志刚[1] 李顺[1] 周晓辉[1] YANG Hua;ZHAO Yong;SONG Zhigang;LI Shun;ZHOU Xiaohui(Shanghai Public Health Clinical Center,Shanghai 201508,China;Shanghai Laboratory Animal Research Center,Shanghai 201203,China)

机构地区：[1]上海市公共卫生临床中心,上海201508 [2]上海实验动物研究中心,上海201203

出　　处：《实验动物与比较医学》2020年第2期149-153,共5页Laboratory Animal and Comparative Medicine

摘　　要：实验动物是医学研究广泛应用的重要工具,实验动物和动物实验的生物安全保障是支撑人类生物医学研究与相关科技进步的关键基础条件之一。目前,动物生物安全二级(ABSL-2)实验室已被广泛应用于生命科学和医学研究的多个领域。本文通过介绍ABSL-2实验室管理要点,围绕实验室建筑设计、资质审批及实验项目审批管理、设施运行、人员管理、操作规程、应急处置等方面,如何加强管理,建立一个有效的生物安全管理体系,以防止危害生物因子泄露,提高动物生物安全二级实验室生物安全保障支撑水平,为同行提供信息参考。Laboratory animals represent the important tools which were widely used for medical researches.The biosafety of laboratory animals and animal experiments have provided key base of the development of biomedical science and technology for human society.Currently,the animal biosafety level 2(ABSL-2)laboratory are widely used in the fields of life sciences and medical researches.This review introduces the key points of management of ABSL-2 laboratory,including the structure designing,the administrational approving,the facility running,the management of human resources,the experimental operation,the emergency handling,and how to setup effective biosafety management system to avoid the leakage of bio-hazardous factors,to improve the animal laboratory biosafety level.

关 键 词：生物安全 动物生物安全二级 动物实验 管理体系 

分 类 号：Q95-33[生物学—动物学]