应用自体富血小板血浆治疗手部皮肤缺损的疗效分析  

Clinical application of autologous platelet-rich plasma in repairing skin defect of hand

作　　者：周贤挺 孙涛[1] 薛建波[1] 周映玲[1] 李基民[1] 何凌锋[1] 王晓峰[1] ZHOU Xianting;SUN Tao;XUE Jianbo(Department of Hand Surgery,Ningbo Sixth Hospital,NingBo 315000,China)

机构地区：[1]宁波市第六医院手外科,浙江宁波315000

出　　处：《全科医学临床与教育》2020年第6期510-512,F0002,共4页Clinical Education of General Practice

基　　金：宁波市第六医院院级课题(2018008)。

摘　　要：目的探讨利用自体富血小板血浆对于手部皮肤缺损的临床疗效分析。方法回顾性分析15例手部皮肤缺损患者资料,根据有无肌腱外露分成肌腱外露组(5例)及皮肤缺损组(10例)。比较两组患者的创面愈合时间,创面愈合率及术后5月上肢功能评分(DASH评分)。结果所有患者术后获6~10个月随访,中位随访时间8.60月。15例患者创口愈合良好,未发现创口感染、皮下组织外露等并发症,两组患者的创面愈合率比较,差异无统计学意义(P>0.05)。肌腱外露组的临床愈合时间明显长于皮肤缺损组,术后5月DASH评分明显高于皮肤缺损组,差异有统计学意义(t分别=6.97、2.84,P均<0.05)。结论自体富血小板血浆对治疗手部单纯皮肤缺损具有较好的临床疗效。对小面积肌腱外露创面虽愈后相对较差,但创面均愈合,可作为非手术治疗方案的一种选择。Objective To study clinical efficacy of autologous platelet-rich plasma(PRP)in repairing skin defects of hand.Methods Retrospective analysis of 15 cases with soft tissue defects of hand was performed,according to whether the tendon exposed,5 cases with small-scale tendon exposed were enrolled as tendon exposed group and 10 cases with no tendon exposed were enrolled as the control group.The wound healing time,healing rate and DASH score after 5 months were compared.Results All patients were followed up for average 8.60 months(6 to 10 months)after surgery.All the wounds healed,no complications such as infection,tendon occurred.There was no significant differences in healing rate between the two groups(P>0.05).There were significant differences in wounds healing time and DASH score after 5 months between the two groups(t=6.97,2.84,P<0.05).Conclusion PRP can obtain a better clinical effect on the skin defect of hand without tendon exposed.PRP can be an option of non-surgical treatment for patients with tendon exposed.

关 键 词：自体富血小板血浆 皮肤缺损 愈合 肌腱外露 

分 类 号：R658.2[医药卫生—外科学]