新型单面刻槽药物洗脱支架的制备与研究  

Preparation and Study of Novel Abluminal Groove Drug-eluting Stents

作　　者：尧婉辰 孙怀远 张劼 金文涛 YAO Wanchen;SUN Huaiyuan;ZHANG Jie;JIN Wentao(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai,200093;School of Medical Instrument,Shanghai University of Medicine and Health Sciences,Shanghai,201318;Shanghai Microport Medical Device Co.Ltd.,Shanghai,201203)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海健康医学院医疗器械学院,上海201318 [3]上海微创医疗器械有限公司,上海201203

出　　处：《生物医学工程学进展》2020年第2期63-67,共5页Progress in Biomedical Engineering

基　　金：上海市生物医学工程学科建设项目(E1-2601-17-201002 Shanghai Education Commission)。

摘　　要：为研究单面刻槽支架表面载药涂层的制备,采用压电微喷技术制备以聚乳酸(PLA)为载药物的雷帕霉素药物洗脱支架。通过调节影响压电微喷技术的主要参数,使涂层效果达到最优,并对支架表面的凹槽进行扫描和识别,以制备药物洗脱支架。利用球囊扩张实验来检验载药涂层与支架基体之间的结合情况,并在扫描电子显微镜(SEM)下观测扩张前后药物洗脱支架表面涂层的形貌特征;在PBS缓冲液中对制备的药物洗脱支架进行体外模拟实验,并绘制药物释放的动力学曲线。结果表明:压电微喷技术应用于单面刻槽支架表面载药涂层制备具有可行性,能实现对凹槽的精准喷涂,并且经球囊扩张后的支架表面涂层牢固度达到要求,药物释放曲线也能够满足释放要求。In order to study the preparation of drug-loading coating on the surface of abluminal grooves stent,rapamycin loaded PLA eluting stent was prepared by piezoelectric microinjection technique.The coating effect was optimized by adjusting the main parameters of piezoelectric microinjection technology,and the grooves on the surface of the stent were scanned and identified to prepare drug-eluting stents.Balloon dilatation experiment was used to evaluate the combination between drug-loading coating and scaffold substrate,and the morphology of drug-eluting stent surface coating before and after dilatation was observed under scanning electron microscope(SEM).The in vitro release behavior of drug-eluting stent was characterized assessed in PBS buffer,and the kinetics curve of drug release was plotted.The results showed that the application of piezoelectric micro-jet technology in the preparation of drug-loading coating on the surface of abluminal grooves stent was feasible,and the precision spraying of the grooves could be achieved.Moreover,the firmness of coating on the surface of the stent after balloon expansion met the requirements,and the drug release curve could also meet the release requirements.

关 键 词：单面刻槽支架 压电微喷技术 载药涂层 球囊扩张 体外释放 

分 类 号：R318[医药卫生—生物医学工程] TP391[医药卫生—基础医学]