不同氧流量驱动肝素雾化吸入对老年COPD合并呼吸衰竭患者临床疗效的改善作用  

Improvement Effect of Different Oxygen Flow-Driven Heparin Aerosol Inhalation on Clinical Efficacy of Elderly Patients with COPD Complicated with Respiratory Failure

作　　者：唐宇乐 谭海涛 阮世冲 朱义红 林志光 TANG Yule;TAN Haitao;RUAN Shichong;ZHU Yihong;LIN Zhiguang(Department of Respiratory Medicine,Yangjiang People's Hospital,Yangjiang 529500,China;Department of General Medicine,Yangjiang People's Hospital,Yangjiang 529500,China;Department of Infectious Medicine,Yangjiang People's Hospital,Yangjiang 529500,China;Department of Radiology,Yangdong District People's Hospital,Yangjiang 529900,China)

机构地区：[1]阳江市人民医院呼吸内科,广东阳江529500 [2]阳江市人民医院全科,广东阳江529500 [3]阳江市人民医院感染内科,广东阳江529500 [4]阳江市阳东区人民医院放射科,广东阳江529900

出　　处：《临床医学工程》2020年第6期801-802,共2页Clinical Medicine & Engineering

摘　　要：目的探讨不同氧流量驱动肝素雾化吸入治疗老年COPD合并呼吸衰竭患者的临床疗效。方法 150例COPD合并呼吸衰竭患者随机分为三组各50例,患者均采用氧流量驱动肝素雾化吸入治疗,氧流量A组为5 L/min, B组为7 L/min, C组为9 L/min。比较三组治疗前后的Copeptin水平、痰液粘稠度评分以及呼吸力学指标。结果治疗后,三组的Copeptin水平和痰液粘稠度评分均显著下降(P <0.05), B组的Copeptin水平和痰液粘稠度评分显著低于A组、 C组(P <0.05)。治疗后,三组的Ppeak、 Pplat、 Raw均显著下降,Cd显著升高(P <0.05);B组的Ppeak、 Pplat、 Raw均显著低于A组、 C组,Cd显著高于A组、 C组(P <0.05)。结论氧流量7 L/min驱动肝素雾化吸入治疗老年COPD合并呼吸衰竭可有效改善患者的痰液粘稠度和血浆Copeptin水平,改善呼吸力学指标,具有较高的临床应用价值。Objective To explore the clinical efficacy of different oxygen flow-driven heparin aerosol inhalation in the treatment of elderly patients with COPD complicated with respiratory failure.Methods 150 elderly patients with COPD complicated with respiratory failure were randomly divided into three groups,with 50 cases in each group.All patients were treated with oxygen flow-driven heparin aerosol inhalation,and the oxygen flow was 5 L/min in group A,7 L/min in group B,and 9 L/min in group C.The Copeptin levels,sputum viscosity scores and respiratory mechanics indicators before and after treatment were compared among three groups.Results After treatment,the Copeptin levels and sputum viscosity scores of three groups decreased significantly(P<0.05);The Copeptin level and sputum viscosity score of group B were significantly lower than those of group A and group C(P<0.05).After treatment,Ppeak,Pplat and Raw of three groups decreased significantly,and Cd increased significantly(P<0.05);Ppeak,Pplat and Raw of group B were significantly lower than those of groups A and group C,and Cd was significantly higher than that of group A and group C(P<0.05).Conclusions Oxygen flow 7 L/min driven heparin aerosol inhalation in the treatment of elderly COPD complicated with respiratory failure can effectively improve patients'sputum viscosity and plasma Copeptin level,and improve the respiratory mechanics indicators,which has high clinical application value.

关 键 词：慢性阻塞性肺疾病 呼吸衰竭 肝素 氧流量 雾化吸入 

分 类 号：R563[医药卫生—呼吸系统]