小儿益气平喘颗粒治疗小儿咳嗽变异性哮喘缓解期肺脾气虚证84例临床观察  

Clinical observation on 84 cases of children with cough variant asthma in remission stage with deficiency of lung and spleen qi syndrome treated by Xiao’er Yiqi Pingchuan Keli(小儿益气平喘颗粒)

作　　者：邱艳艳 张林猛[1] 贾岩辉[1] 张玉倩[1] 王醊恩[2] QIU Yanyan;ZHANG Linmeng;JIA Yanhui;ZHANG Yuqian;WANG Zhui'en(Department of Rehabilitation,Binzhou Central Hospital,Binzhou,Shandong,251700,China;Teaching and Research Section of TCM Classic,Binzhou Medical College,Yantai,Shandong,264003,China)

机构地区：[1]滨州市中心医院康复科,山东滨州251700 [2]滨州医学院中医经典教研室,山东烟台264003

出　　处：《中医儿科杂志》2020年第3期37-40,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察小儿益气平喘颗粒治疗小儿咳嗽变异性哮喘(CVA)缓解期肺脾气虚证的临床疗效。方法选取2017年1月至2019年1月于滨州市中心医院儿科门诊就诊的CVA缓解期肺脾气虚证患儿共172例,按照随机数字表法分为治疗组和对照组,各86例。对照组予二丙酸倍氯米松定量气雾剂,治疗组予小儿益气平喘颗粒口服。2组在治疗过程中若出现急性感染,则加服希舒美,连续服用不超过5 d。2组均治疗6个月后统计疗效。结果对照组总有效率为78.0%(64/82),治疗组为92.8%(78/84),2组比较,差异有统计学意义(P<0.05)。治疗前,2组用力肺活量(FVC)、最大呼气峰流速(PEF)、第1秒用力呼气量(FEV1)、FEV1/FVC指标比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标均显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高更显著(P<0.05)。治疗前,2组IgA、IgG、IgE和CD+3、CD+8、CD+4/CD+8水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,治疗组IgA、IgG、CD+3、CD+8水平明显升高,IgE、CD+4、CD+4/CD+8水平明显下降,对照组除CD+8和CD+4/CD+8指标外,其他指标也明显升高或下降,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组升高或下降更显著(P<0.05)。治疗前,2组炎症因子白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组IL-6、TNF-α水平均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。结论小儿益气平喘颗粒治疗小儿CVA缓解期肺脾气虚证,可以明显改善患儿的肺功能、免疫功能及炎症状态,临床效果显著,值得临床推广应用。Objective To observe the clinical efficacy of Xiao’er Yiqi Pingchuan Keli(小儿益气平喘颗粒) in the treatment of children with cough variant asthma(CVA) in remission stage with deficiency of lung and spleen qi syndrome.Methods Totally 172 cases with CVA in remission stage with deficiency of lung and spleen qi syndrome consulted in pediatric outpatient department in Binzhou Central Hospital from January 2017 to January 2019 were divided into treatment group and control group according to random number table method,with 86 cases in each.The control group was given beclomethasone dipropionate aerosol quantitative,the treatment group was given oral administration of Xiao’er Yiqi Pingchuan Keli.If there was acute infection in the 2 groups during the treatment,oral supplemented zithromaxthe and the continuous administration not more than 5 days.We kept statistics about the curative effects after the 2 groups were both treated for 6 months.Results The total effective rate of the control group was 78.0%(64/82),that of the treatment group was 92.8%(78/84),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the difference was not statistically significant in the indexes of forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in 1 s(FEV1) and FEV1/FVC between the 2 groups(P>0.05),and they were comparable.After treatment,the above-mentioned indexes in the 2 groups all significantly increased,and the difference was statistically significant compared with the same group before treatment(P<0.05), moreover,the treatment group increased more significantly(P<0.05).Before treatment,the difference was not statistically significant in the levels of immunoglobulin(Ig)A,IgG,IgE,CD+3,CD+8 and CD+4/CD+8 between the 2 groups(P>0.05),and they were comparable.After treatment, the levels of IgA,IgG,CD+3 and CD+8 in the treatment group all significantly increased,while the levels of IgE,CD+4 and CD+4/CD+8 significantly decreased.In the control group, except the ind

关 键 词：咳嗽变异性哮喘 缓解期 肺脾气虚证 小儿益气平喘颗粒 临床观察 

分 类 号：R256.12[医药卫生—中医内科学]