抽动障碍动物模型的研究进展  

Research advances in animal models of tic disorder

作　　者：柯钟灵 陈燕惠[1] KE Zhongling;CHEN Yanhui(Fujian Medical University Union Hospital,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属协和医院,福州350000

出　　处：《中国实验动物学报》2020年第3期416-422,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：福建省教育厅中青年教师科研项目(JT180171)。

摘　　要：抽动障碍是儿童期常见的神经发育性疾病,主要表现为不自主地重复的、突然的动作和/或发声,可伴有注意缺陷多动障碍、学习障碍、强迫症、品行障碍等,严重影响患儿学习、社会适应能力及心理的健康发展。但其病因及发病机制、药理机制尚未完全明确,这些基础研究需要通过动物模型进行进一步的探索及验证。目前存在多种抽动障碍模型的构建方法,主要是基于该病可能的发病机制,如神经递质异常、免疫功能紊乱、遗传因素等,但尚无一种动物模型能够完全符合抽动障碍的表现,本文对抽动障碍常用的动物模型进行了总结,以期为实验研究提供参考。Tic disorder is a common neurodevelopmental disease in childhood,which is mainly manifested as involuntary repetition,sudden movement and/or phonation,and may be accompanied by attention deficit hyperactivity disorder,learning disorder,obsessive-compulsive disorder,conduct disorder,etc.,seriously affecting the children’s learning,social adaptability and psychological healthy development.However,its etiology,pathogenesis and pharmacological mechanism have not been fully clarified,and these basic studies need to be further explored and verified through animal models.At present,there are a variety of construction method of tic disorder models,mainly based on the possible pathogenesis of the disease,such as neurotransmitter abnormalities,immune dysfunction,genetic factors,etc.,but there is no animal model that can completely meet the manifestations of tic disorder.This paper summarizes the commonly used animal models of tic disorder,in order to provide a reference for experimental studies.

关 键 词：抽动障碍 动物模型 啮齿类 病因 发病机制 

分 类 号：Q95-33[生物学—动物学]