血友病鼠关节病模型构建研究进展  

Progress in construction of a hemophilic arthropathy mouse model

作　　者：孙庆云 闫振宇 SUN Qingyun;YAN Zhenyu(North China University of Science and Technology,Tangshan 063000,China;the Affiliated Hospital of North China University of Science and Technology,Tangshan 063000)

机构地区：[1]华北理工大学,河北唐山063000 [2]华北理工大学附属医院,河北唐山063000

出　　处：《中国实验动物学报》2020年第3期423-428,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：2019年河北省政府资助临床医学优秀人才培养项目。

摘　　要：血友病性关节病是由自发性关节内出血及反复关节内血肿引起,是以慢性疼痛,关节损伤,生活质量下降为主要临床表现的一种衰竭性疾病。其生物学机制尚不完全清楚。目前血友病的转化动物模型对于确定该疾病的病理生理学及其并发症具有重要价值。因此,需要建立一种血友病性关节病模型,以便进一步研究血友病性关节病的病理生理机制以及潜在的干预治疗。血友病鼠因便于运输,便于构建等优势成为研究者青睐的动物模型,其构建的血友病性关节病模型也为今后的临床研究提供了基础。为此,将对血友病鼠关节病模型的构建及研究展开叙述。Hemophilic arthropathy is caused by spontaneous intra-articular hemorrhage and repeated intra-articular hematomas.Chronic pain,joint damage and decreased quality of life are the main clinical manifestations of hemophilic arthropathy.The biological mechanisms are not fully understood.Current translational animal models of hemophilia are of great value in determining the pathophysiology of the disease and its complications.Therefore,a hemophilic arthropathy mouse model was established to further investigate the pathophysiological mechanisms of hemophilic arthropathy as well as potential intervention treatments.A murine model of hemophilia provides advantages as an animal model for research because of easy transportation and easy construction,and its constructed hemophilic arthropathy model also provides the basis for future clinical research.This review will describe the construction and investigation of a mouse model of hemophilia arthropathy.

关 键 词：动物模型 关节出血 血友病 鼠属 

分 类 号：Q95-33[生物学—动物学]