白细胞介素-27基因多态性与广西壮族人群冠心病发病风险的相关性研究  

Correlation between interleukin-27 polymorphisms and coronary heart disease in the Guangxi Zhuang Population

作　　者：薛焱[1] 刘海润[2] 杨子聪[1] 卢建勇 黄信顺 黄瑛[3] 刘宇[1] 刘伶[1] 施莹[1] Xue Yan;Liu Hairun;Yang Zicong;Lu Jianyong;Huang Xinshun;Huang Ying;Liu Yu;Liu Ling;Shi Ying(Department of Cardiology,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Cognitive and Sleep Center,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Ultrasound,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院心血管内科,南宁530021 [2]广西壮族自治区人民医院认知睡眠中心,南宁530021 [3]广西壮族自治区人民医院超声科,南宁530021

出　　处：《中华老年医学杂志》2020年第6期632-635,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(81460061,81460081);广西医疗卫生适宜技术研究与开发项目(S2015-46)。

摘　　要：目的:探讨白细胞介素-27(IL-27)基因多态性与广西壮族人群冠心病发病风险的相关性。方法:病例对照研究,共纳入研究对象1218例,其中冠心病组571例,非冠心病对照组647例,采用Sequenom MassArray系统对IL-27单核苷酸多态性(SNPs)位点进行基因分型,相关生化指标均由广西壮族自治区人民医院检验科按标准流程进行检测。使用Logistic回归分析对IL-27基因位点多态性与冠心病的相关性进行探讨,并对年龄、吸烟史、饮酒史及高血压、糖尿病、冠心病家族史等相关危险因素进行校正。结果:Logstic回归分析结果提示,广西壮族人群中IL-27 rs428253基因位点CC基因型者较GG基因型者冠心病发病风险增高(OR=2.18,95%CI:1.09~4.37,P<0.05),进一步对相关危险因素校正后,结果仍提示rs428253 CC等位基因携带者较GG等位基因携带者冠心病发病风险增加(OR=2.82,95%CI:1.31~6.07,P<0.05),未发现IL-27 rs4740、rs17855750、rs181206及rs40837位点基因多态性与广西壮族人群冠心病的发病风险存在相关性(均P>0.05)。进一步研究结果提示,冠心病组和对照组内rs428253不同基因型间C-反应蛋白、总胆固醇、三酰甘油及低密度脂蛋白胆固醇差异无统计学意义(均P>0.05)。结论:IL-27 rs428253基因位点多态性与广西壮族人群冠心病的发病风险存在相关性。Objective To investigate the correlation between interleukin-27(IL-27)polymorphisms and coronary heart disease(CHD)in the Guangxi Zhuang population.Methods A total of 1218 subjects were enrolled in this case-control study,and 571 cases were in the CHD group and 647 were in the control group.The Sequenom MassArray system was used to genotype IL-27 single nucleotide polymorphisms(SNPs),and other biochemical parameters were tested by using the standard protocol in the laboratory of our hospital.The correlation between IL-27 SNPs and CHD was evaluated by Logistic regression analysis,and risk factors including age,smoking,drinking,history of hypertension,history of diabetes mellitus and family history of CHD were adjusted in this model.Methods Logistic regression analysis results indicated that the risk of CHD was elevated in subjects with the CC genotype of IL-27 rs428253,compared with those with the GG genotype(OR=2.18,95%CI:1.09-4.37,P<0.05).After adjustment for the related risk factors,the risk of CHD also increased in subjects with the CC genotype of IL-27 rs428253,compared with those with the GG genotype(R=2.82,95%CI:1.31-6.07,P<0.05).IL-27 rs4740,rs17855750,rs181206 and rs40837(all P>0.05)polymorphisms had no correlation with CHD in the Zhuang population,and there were no significant differences in C-reactive protein,total cholesterol,triglyceride or low-density lipoprotein cholesterol levels between CHD patients and controls with different genotypes of IL-27 rs428253(all P>0.05).Conclusions IL-27 rs428253 polymorphism is correlated with the risk of CHD in the Guangxi Zhuang population.

关 键 词：白细胞介素-27 多态性 单核苷酸 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]