丹参多酚酸盐导致自身免疫性溶血性贫血的检测及输血效果评价  

Detection of Autoimmune Hemolytic Anemia Induced by Salvianolate and Evaluation of Blood Transfusion Efficacy

作　　者：马春娅[1] 罗圆圆[1] 杨璐[1] 封彦楠 孙晓琳[1] 邹文娟[1] 汪德清[1] 于洋[1] MA Chun-Ya;LUO Yuan-Yuan;YANG Lu;FENG Yan-Nan;SUN Xiao-Lin;ZOU Wen-Juan;WANG De-Qing;YU Yang(Department of Blood Transfusion,Center for Clinical Transfusion Medicine,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院输血科,解放军临床输血中心,北京100853

出　　处：《中国实验血液学杂志》2020年第3期904-908,共5页Journal of Experimental Hematology

摘　　要：目的:通过药物抗体检测及临床指标监测,评价丹参多酚酸盐导致的自身免疫性溶血性贫血的特点。方法:应用微柱凝胶抗人球蛋白法进行不规则抗体筛查、抗体鉴定试验;用丹参多酚酸盐、磷酸肌酸钠、左卡尼汀致敏与患者配血相合的红细胞,检测患者血浆中是否存在对应的药物抗体;回顾性分析患者临床溶血指标及输血效果。结果:患者不规则抗体筛查阳性,血清内存在类抗-Ce联合抗体;患者血清与丹参多酚酸盐致敏的红细胞反应为阳性,与磷酸肌酸钠、左卡尼汀致敏的红细胞反应为阴性;结论:丹参多酚酸盐导致该患者发生自身免疫性溶血性贫血。Objective:To evaluate the characteristics of autoimmune hemolytic anemia caused by salvianolate by antibody detection and clinical index monitoring.Methods:Micro-column gel anti-human globulin method was used for irregular antibody screening and antibody identification.Salvianolate,sodium creatine phosphate and levocarnitine were used to sensitize red blood cells that were compatible with the patient′s plasma,and the RBCs were used to test drug antibody in patient plasma respectively.The patient′s clinical examination of hemolysis index and blood transfusion effect were analyed retrospectively.Results:The patients were positive for irregular antibody screening,and there were antoanti-Ce antibodies in serum.The erythrocytes sensitized with salvianolate in the patient′s serum were positive,while those sensitized with sodium creatine phosphate and levocarnitine were negative.Conclusion:Salvianolate causes druginduced autoimmune hemolytic anemia in this patient.

关 键 词：丹参多酚酸盐 药物自身免疫性溶血性贫血 不规则抗体 类抗体 输血效果 

分 类 号：R457.13[医药卫生—治疗学]