成人大骨节病患者血清一氧化氮含量变化的Meta分析  

Serum nitric oxide content in adult patients with Kaschin-Beck disease:A Meta-analysis

作　　者：王明君 张强[1] 姜泓[1] 马静[1] 李亚楠[1] 陈勋[1] 沈洪婷[1] 蒲光兰[1] 何多龙[1] Wang Mingjun;Zhang Qiang;Jiang Hong;Ma Jing;Li Yanan;Chen Xun;Shen Hongting;Pu Guanglan;He Duolong(Department for Endemic Disease Prevention and Control,Qinghai Institute for Endemic Disease Prevention and Control,Xining 811602,China)

机构地区：[1]青海省地方病预防控制所地方病预防控制科,西宁811602

出　　处：《中华地方病学杂志》2020年第6期447-450,共4页Chinese Journal of Endemiology

基　　金：青海省科技计划项目(2014-ZJ-754);青海省卫健委指导项目(2016-wjzdx-37);第二次青藏高原综合科学考察研究资助(2019QZKK0607)。

摘　　要：目的系统评价成人大骨节病患者血清一氧化氮(NO)含量的变化。方法对中国知网(CNKI)、万方数据知识服务平台(WanFang Data)、维普中文期刊(VIP)、PubMed、Embase等数据库进行系统检索,分析检索时间为建库至2019年3月31日公开发表的成人大骨节病患者血清NO含量变化的文献。采用Revman 5.3软件进行Meta分析,计算平均差(MD)及95%置信区间(CI);根据异质性结果应用固定效应模型或随机效应模型进行敏感性分析;利用漏斗图评估发表偏倚。结果最终纳入符合要求的研究文献7篇,成人大骨节病组358例,对照组305例。经异质性检验,各文献间存在异质性(χ2=188.07,I2=97%,P<0.01),故采用随机效应模型进行Meta分析。大骨节病组血清NO含量明显高于对照组(MD=44.29,95%CI:30.57~58.00),差异有统计学意义(Z=6.33,P<0.01)。敏感性分析结果显示,本研究结果稳定。漏斗的两侧各研究基本对称,提示存在发表偏倚的可能性较小。结论成人大骨节病患者血清NO含量明显升高。Objective To systematically evaluate the changes of serum nitric oxide(NO)content in adult patients with Kaschin-Beck disease(KBD).Methods Systematic retrieval was conducted on China National Knowledge Infrastructure(CNKI),WanFang Data,VIP Database,PubMed,Embase and other databases,to analyze the literatures published from the database establishment to March 31,2019,on the changes of serum NO content of adult patients with KBD.Meta-analysis was performed using Revman 5.3 software,and mean difference(MD)and 95%confidence interval(CI)were calculated;sensitivity analysis was performed using fixed-effect model or random-effect model based on heterogeneity results;and publication bias was evaluated using funnel chart.Results Totally 7 qualified literatures were included,including 358 cases in the adult KBD group and 305 cases in the control group.After the heterogeneity test,there was heterogeneity among the literatures(χ2=188.07,I2=97%,P<0.01),so a random-effect model was used for Meta-analysis.The NO content in the KBD group was significantly higher than that in the control group(MD=44.29,95%CI:30.57-58.00),the difference was statistically significant(Z=6.33,P<0.01).Sensitivity analysis showed that the results of this study were stable.The two sides of the funnel were basically symmetrical,suggesting that the possibility of publication bias was small.Conclusion The serum level of NO content in adult patients with KBD is significantly increased.

关 键 词：大骨节病 一氧化氮 META分析 

分 类 号：R684.1[医药卫生—骨科学]