伏硫西汀与文拉法辛治疗伴认知功能损害抑郁症临床疗效对比  

Comparative Study of Vortioxetine Versus Venlafaxine on Depression with Cognitive Impairment

作　　者：周小艳[1] 冉江峰[1] 范征莉[1] 杨辉[1] 黄雪萍[1] ZHOU Xiaoyan;RAN Jiangfeng;FAN Zhengli;YANG Hui;HUANG Xueping(Chongqing Mental Health Center,Chongqing,China 401147)

机构地区：[1]重庆市精神卫生中心,重庆401147

出　　处：《中国药业》2020年第12期79-81,共3页China Pharmaceuticals

基　　金：重庆市科卫联合医学科研项目[2018MSXM071]。

摘　　要：目的比较伏硫西汀与文拉法辛治疗伴认知功能损害抑郁症的临床疗效及对患者认知功能的改善效果。方法选取医院临床心理科2018年9月至2019年8月收治的伴认知功能损害的抑郁症患者70例,按随机数字表法分为观察组和对照组,各35例,分别给予氢溴酸伏硫西汀片与盐酸文拉法辛缓释片口服,观察8周。结果观察组总有效率为85.71%,与对照组的82.86%相当(P>0.05);两组患者治疗第2,4,6,8周末的汉密尔顿抑郁量表(HAMD)评分均逐渐降低,与治疗前比较有明显差异(P<0.05);治疗后,观察组威斯康星卡片分类测验(WCST)总数、持续错误数及随机错误数均明显减少,且观察组明显低于对照组(P<0.05);两组不良反应发生率相当(8.57%比5.71%,P>0.05)。结论相较于文拉法辛,伏硫西汀治疗伴认知功能损害抑郁症效果更好。Objective To compare the clinical efficiency of vortioxetine and venlafaxine in the treatment of depression with cognitive impairment and the improvement of cognitive function.Methods A total of 70 cases of depressive patients with cognitive impairment admitted to the Department of Clinical Psychology in the hospital from September 2018 to August 2019 were selected and divided into the observation group and control group according to random number table method,35 cases in each group.The two groups were given vortioxetine hydrobromide tablets and venlafaxine sustained-release tablets respectively for 8 weeks under observation.Results The total effective rate of the observation group was 85.71%,which had no significantly difference with 82.86%in the control group(P>0.05).The Hamilton Depression Scale(HAMD)scores of the two groups decreased gradually at the 2nd,4th,6th,and 8th weeks,and had significantly differences compared with before treatment(P<0.05).After treatment,the total number of Wisconsin Card Sorting Test(WCST),the number of persistent errors,and the random errors in the observation group were significantly decreased and were significantly lower than the control group(P<0.05).The difference of adverse reactions between the two groups was not significant(8.57%vs.5.71%,P>0.05).Conclusion Vortioxetine is better than venlafaxine in treating depression with cognitive impairment.

关 键 词：伏硫西汀 文拉法辛 抑郁症 认知功能损害 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R971.43[医药卫生—药学]