柴葛解肌颗粒醇沉工艺对石膏成分保留及解热作用的影响  

Study on the effects of alcohol precipitation process of Chaige Jieji granules on the retention of Gypsum Fibrosum components and antipyretic effect

作　　者：吴静鸣 黄晓青 曹阳 黄顺旺 WU Jingming;HUANG Xiaoqing;CAO Yang;HUANG Shunwang(Anhui Tianxing Pharmaceutical Group Co.,Ltd.,Hefei,Anhui 230601,China;Hefei Innovative Medical Technology Co.,Ltd.,Hefei,Anhui 230088,China)

机构地区：[1]安徽天星医药集团有限公司,安徽合肥230601 [2]合肥创新医药技术有限公司,安徽合肥230088

出　　处：《安徽医药》2020年第7期1295-1297,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的通过研究石膏成分保留及解热作用,探讨柴葛解肌颗粒醇沉工艺合理性。方法采用络合滴定法测定柴葛解肌颗粒醇沉前后浸膏中含水硫酸钙含量,采用2,4-二硝基苯酚致大鼠发热模型、内毒素致家兔发热模型,对其解热药效作用进行对比研究。结果醇沉前后浸膏均具有一定的解热作用,且与阳性药组比较,三者差异无统计学意义。结论柴葛解肌颗粒醇沉工艺合理。ObjectiveThe rationality of alcohol precipitation process of Chaige Jieji granules was discussed by studying the retention of Gypsum Fibrosum components and antipyretic effect.MethodsThe study determined the content of Ca SO4·2 H2 O in the extracts of Chaige Jieji granules before and after alcohol precipitation by complexometric titration,and used fever models induced by2,4-dinitrophenol in rats and by endotoxin in rabbits to compare their antipyretic effects.ResultsThe extracts both had antipyretic effect.Compared with positive drug group,there was no significant difference between the three groups.ConclusionThe alcohol precipitation process is reasonable and feasible.

关 键 词：中药工艺改进 柴葛解肌汤 石膏 硫酸钙 解肌清热 醇沉工艺 

分 类 号：TQ461[化学工程—制药化工]