NGF/TrKA信号轴在骨关节炎中的研究进展  

Role of NGF/TrKA signal axis in osteoarthritis

作　　者：何良志 路凡 滕飞 李睿[1,2] 耿彬 姜金[1,2] 夏亚一 HE Liang-zhi;LU Fan;TENG Fei;LI Rui;GENG Bin;JIANG Jin;XIA Ya-yi(The Second Hospital Affiliated to Lanzhou University,Lanzhou 730030,China;Key Laboratory of Orthopedics of Gansu Province,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院骨科 [2]甘肃省骨与关节疾病重点实验室,兰州730030

出　　处：《中国矫形外科杂志》2020年第11期933-936,共4页Orthopedic Journal of China

基　　金：国家自然科学基金项目(编号:81874017);兰州市科技计划项目(编号:2017-4-88和2018-3-52);兰州大学第二医院院内博士科研基金项目(编号:ynbskyjj2015-2-9);兰州大学第二医院“萃英科技创新”计划项目(编号:CY2017-ZD02和CY2017-QN12)。

摘　　要：骨关节炎(osteoarthritis,OA)是以关节软骨退行性变和继发性骨质增生为特征的慢性膝关节疾病,疼痛是骨关节炎患者最早出现、最主要的症状。随着其他类型镇痛药物不良反应的增加,迫切需要新型镇痛药物的出现。本文介绍了神经生长因子(nerve growth factor,NGF)/原肌球蛋白受体激酶A(tropomyosin receptor kinase A,TrKA)信号轴在疼痛发生中的作用及发病机制的研究进展,针对NGF/TrKA信号轴相关的镇痛药物,包括NGF抑制剂、抑制NGF与TrKA结合的镇痛药和TrKA抑制剂,为骨关节炎患者的治疗提供更多的药物选择。Osteoarthritis is a chronic knee disease characterized by joint cartilage degeneration and secondary hyperostosis.Pain is the earliest and most important symptom of osteoarthritis patients.With the increase of adverse reactions to other types of analgesic drugs,there is an urgent need for the emergence of new analgesic drugs.In this review,we introduced the role of nerve growth factor(NGF)/tropomyosin receptor kinase A(TrKA)signal axis in pain occurrence,advance of NGF/TrKA research in the pain and pathogenesis in patients with osteoarthritis,and analgesic drugs associated with NGF/TrKA signal axis,including NGF inhibitors,analgesics that inhibit the combination of NGF and TrKA,and TrKA inhibitors,to provide more drug options for treatment of patients with osteoarthritis.

关 键 词：骨关节炎 疼痛 神经生长因子(NGF) 原肌球蛋白受体激酶(TrKA) 

分 类 号：R684.3[医药卫生—骨科学]