miRNA在动物毛囊发育中的研究进展  

Research Progress of miRNA in Animal Hair Follicle Development

作　　者：刘公言 白莉雅[1] 李福昌[2] 常莹[3] 姜文学[1] 杨丽萍[1] 孙海涛[1] 高淑霞[1] Liu Gongyan;Bai Liya;Li Fuchang;Chang Ying;Jiang Wenxue;Yang Liping;Sun Haitao;Gao Shuxia(Animal Husbandry and Veterinary Institute,Shandong Academy of Agricultural Sciences/Shandong Key Laboratory of Livestock and Poultry Diseases Control and Breeding,Jinan 250100,China;College of Animal Science and Technology,Shandong Agricultural University,Taian 271018,China;Shandong Animal Husbandry Association,Jinan 250100,China)

机构地区：[1]山东省农业科学院畜牧兽医研究所/山东省畜禽疫病防治与繁育重点实验室,山东济南250100 [2]山东农业大学动物科技学院,山东泰安271018 [3]山东省畜牧协会,山东济南250100

出　　处：《山东农业科学》2020年第6期154-159,共6页Shandong Agricultural Sciences

基　　金：国家自然科学基金项目(31972594);山东省自然科学基金项目(ZR2018MC025);山东省现代农业产业技术体系特种经济动物创新团队建设项目(SDAIT-21);2017年山东省农业良种工程(南种北繁)项目(2017LZN008);山东省农业重大应用技术创新兔舍环境测控设备及大数据分析应用平台项目(SF1805301301)。

摘　　要：microRNA (miRNA)是一类长度约20~25个核苷酸的内源性非编码小分子RNA,通过作用于靶基因mRNA的非翻译区抑制其翻译进而参与基因转录后调控,从而影响生物发育和疾病发生过程等。miRNA通过调节Wnt信号通路、BMP信号通路和细胞因子等表达参与动物毛囊的周期性生长发育、毛囊干细胞的增殖分化和凋亡以及被毛颜色的形成等。本研究从miRNA生物合成、miRNA对毛囊发育作用和对动物毛囊发育调控机制等方面进行详细阐述,旨在为深入了解miRNA调控动物毛囊的发育机制,并为今后指导毛用和皮用动物选育和提高生产性能提供参考。microRNA(miRNA)is a class of endogenous non-coding small molecule RNA with a length of about 20~25 nucleotides.It inhibits the translation process by combining with the un-translated region of target gene mRNA,and then participates in the post transcriptional regulation of gene,thus affects the biological development and the occurrence of diseases.miRNA is involved in the periodic growth and development of hair follicles,the proliferation,differentiation and apoptosis of hair follicle stem cells,and the formation of coat color through regulating the Wnt signaling pathway,BMP signaling pathway and cytokines expression.In the paper,the biological formation of miRNA,the miRNA role in hair follicle development and its regulatory mechanism in animal hair follicle development was studied detailedly,so as to better understand the mechanism of miRNA regulating the development of animal hair follicles and provide references for fur animal breeding and improving production performance in future.

关 键 词：MICRORNA 毛囊 发育 

分 类 号：S-1[农业科学] Q522.5[生物学—生物化学]