儿童危重多发性大动脉炎的诊治进展  

Advance on diagnosis and treatment of children with severe Takayasu arteritis

作　　者：屠志强[1] 李晓忠[2] Tu Zhiqiang;Li Xiaozhong(Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200001,China;Children′s Hospital Affiliated to Soochow University,Suzhou 215025,China)

机构地区：[1]上海交通大学医学院附属仁济医院,200001 [2]苏州大学附属儿童医院肾脏免疫科、儿童血液净化室、免疫研究室,215025

出　　处：《中国小儿急救医学》2020年第5期336-340,共5页Chinese Pediatric Emergency Medicine

基　　金：苏州市儿童免疫性疾病诊治重点实验室(SZ20I808)。

摘　　要：儿童多发性大动脉炎是儿童时期发生的大血管炎,其具有潜在生命危险。早期临床表现无特异性,其损伤常导致器官的缺血性功能障碍。目前非侵入性技术(如磁共振血管造影)已纳入患儿的诊断和随访工作中。儿童多发性大动脉炎目前常规治疗方案是糖皮质激素和免疫抑制剂联合使用,在难治性病例中,应尽快考虑使用生物制剂,以防止缺血对终末器官的损害。当动脉狭窄严重时,需要使用血管内支架或球囊,或旁路介入术来重建受影响器官的血管。早期诊断和及时、正确管理对于降低发病率和器官损害至关重要。Children Takayasu arteritis(c-TA)is a potentially life-threatening macrovasculitis that occurs during childhood.The early clinical manifestations are nonspecific,and the damage often leads to ischemic dysfunction of the organ.Non-invasive techniques such as magnetic resonance angiography has been included in the diagnosis and follow-up of children.At present,the conventional treatment plan is the combination of glucocorticoid and immunosuppressant.In the cases of refractory venereal diseases,biological agents should be considered as soon as possible to prevent the damage of ischemia to the terminal organs.When artery stenosis is severe,intravascular(stent or balloon)or bypass intervention is needed to reconstruct the blood vessels of the affected organs.Early diagnosis and timely and correct management are of vital importance in reducing the incidence rate and risk of injury.

关 键 词：多发性大动脉炎 儿童 诊断 治疗 

分 类 号：R72[医药卫生—儿科]