LncRNA HOTAIR在妇科常见恶性肿瘤的预后方面的Meta分析  

Prognostic Value of lncRNA HOTAIR for Gynecologic Common Malignant Cancer:A Systematic Review and Meta-analysis

作　　者：杨蓓 王霜[2] 温琴琴 林进强 王祥珍[1] YANG Bei;WANG Shuang;WEN Qin-qin(Department of Gynaecology,Nanshan Maternity&Child Healthcare Hospital of Shenzhen,Shenzhen 518000,Guangdong Province,China)

机构地区：[1]深圳市南山区妇幼保健院妇科,广东深圳518000 [2]北京大学深圳医院运动医学科,广东深圳518000

出　　处：《罕少疾病杂志》2020年第4期63-67,共5页Journal of Rare and Uncommon Diseases

摘　　要：目的系统评价lncRNA HOTAIR表达对妇科常见恶性肿瘤预后的潜在价值。方法检索PubMed、Cochran Library、Embase、Web of Science等英文数据库,检索起止时间为建库至2017年08月31日,根据纳入排除标准纳入lncRNA HOTAIR表达和妇科常见肿瘤预后相关的研究,采用NOS进行文献质量评价,用Stata14.0软件对符合条件的所有研究进行Meta分析,计算预后相关指标的HR,并对肿瘤类型以及标本类型进行了亚组分析,最后对纳入文献进行了发表偏倚的评估。结果最终纳入9篇文献,其中病例组636例,对照组458例。lncRNA HOTAIR的合并风险比为HR=2.10,95%CI:1.51-2.93(P=0.000)。在肿瘤类型以及标本类型的亚组分析中,lncRNA HOTAIR的高表达均提示与低OS相关。结论lncRNA HOTAIR有望成为判断妇科常见恶性肿瘤预后的潜在生物标志物。Objective The purpose was to systematically assess the potential role of lncRNA HOTAIR in the prognosis of common gynecologic malignant cancers.Methods Literatures of PubMed,Cochran Library,Embase and Web of Science were searched up to 31th,August,2017.According to the inclusion and exclusion criteria,all studies about lncRNA HOTAIR and the common gynecologic malignant cancers were included and assessed by Newcastle-Ottawa Scale(NOS).Stata 14.0 was used to analyze the data from the literatures and make subgroup analysis.Finally,the publication bias was assessed for all included studies.Results Finally,nine studies were included,covering 636 cases in the experiment group and 458 cases in the control group.LncRNA HOTAIR merger risk ratio was HR=2.10,95%CI:1.51-2.93(P=0.000).In the subgroup analysis of tumor type and specimen type,high expression of lncRNA HOTAIR was relative with low OS.Conclusion LncRNA HOTAIR was expected to be a potential biomarker for the common gynecologic malignant cancers.

关 键 词：lncRNA HOTAIR 妇科恶性肿瘤 META分析 

分 类 号：R271.1[医药卫生—中医妇科学]