小钻化学成分的研究  

Chemical constituents from Kasdsura longipedunculata

作　　者：唐炳兰[1] 覃朗[2] 周小雷[1] 王硕[1] 龚小妹[1] 赵成坚[1] 莫单丹[1] TANG Bing-lan;QIN Lang;ZHOU Xiao-lei;WANG Shuo;GONG Xiao-mei;ZHAO Cheng-Jian;MO Dan-dan(Guangxi Botanical Garden of Medicinal Plants,Key Laboratory of Medicinal Resources Protection and Genetic Improvement in Guangxi,Nanning 530023,China;Guangxi Medical College,Nanning 530023,China)

机构地区：[1]广西药用植物园广西药用资源保护与遗传改良重点实验室,广西南宁530023 [2]广西卫生职业技术学院,广西南宁530023

出　　处：《中成药》2020年第6期1507-1511,共5页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(81660721)。

摘　　要：目的研究小钻Kadsura longipedunculata Finet et Gagnep的化学成分。方法小钻80%乙醇提取物采用硅胶、ODS、Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到9个化合物,分别鉴定为(+)-安五脂素(1)、β-谷甾醇(2)、acetyl-binankadsurin A(3)、二氢愈创木脂素(4)、异型南五味子素G(5)、戈米辛R(6)、isoarborinol(7)、24-烯-环阿尔廷酮(8)、二十四烷酸(9)。结论化合物5~9为首次从该植物中分离得到,化合物7为首次从该属植物中分离得到。AIM To study the chemical constituents from Kadsura longipedunculata Finet et Gagnep.METHODS The 80%ethanol extract from K.longipedunculata was isolated and purified by silica,ODS and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Nine compounds were isolated and identified as(+)-anwulignan(1),β-sitosterol(2),acetyl-binankadsurin A(3),(-)-dihydroguaiaretic acid(4),heteroclitins G(5),gomisin R(6),isoarborinol(7),9,19-cyclolanost-24-en-3-one(8),tetracosanic acid(9).CONCLUSION Compounds 5-9 are isolated from this plant for the first time,and compound 7 is isolated from genus Kasdsura for the first time.

关 键 词：小钻 化学成分 分离鉴定 

分 类 号：R284􀆰[医药卫生—中药学]