缝隙连接蛋白43与心肌缺血再灌注心律失常的研究进展  

Progress in research on connexin 43 and myocardial ischemic-reperfusion arrhythmia

作　　者：陈虹燚 梁仪琳(综述) 黄照河(审校)[2] CHEN Hong-yi;LIANG Yi-lin;HUANG Zhao-he(Graduate School of Youjiang Medical University For Nationalities, Guangxi 533000, China)

机构地区：[1]右江民族医学院研究生学院,广西533000 [2]右江民族医学院附属医院心血管内科,广西533000

出　　处：《中国临床新医学》2020年第6期635-638,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:81860797)。

摘　　要：近年来,心肌缺血再灌注损伤(myocardial ischemic-reperfusion injury,MIRI)的治疗和预防是心血管领域新兴的研究课题之一。缝隙连接(gap junction,GJ)是心脏电生理的基本结构。缝隙连接蛋白(connexin,Cx)是缝隙连接的基本单位。缝隙连接蛋白43(connexin 43,Cx43)是心脏Cx家族中最丰富的成员,Cx43的正常表达对于心脏发育、电耦联的心肌细胞活性和心肌功能的协调至关重要。Cx43与MIRI之间的关系已成为当前研究的重点。该文就Cx43与心肌缺血再灌注心律失常的关系作一综述。In recent years,the treatment and prevention of myocardial ischemic-reperfusion injury(MIRI)is one of the emerging research topics in the cardiovascular field.Gap junction(GJ)is the basic structure of cardiac electrophysiology.Connexin(Cx)is the basic unit of GJ.Connexin 43(Cx43)is the most abundant member of the Cx family in the heart.The normal expression of Cx43 is essential for cardiac development,the coordination of electrically coupled cardiomyocyte activity and myocardial function.The relationship between Cx43 and MIRI has become the focus of current research.This paper reviews the relationship between Cx43 and myocardial ischemic-reperfusion arrhythmia.

关 键 词：缝隙连接蛋白43 心肌缺血再灌注损伤 再灌注心律失常 

分 类 号：R541[医药卫生—心血管疾病]