体外培育熊胆粉对小鼠中枢神经系统作用的一般药理学研究  

General pharmacology study on the effect of Bear Bile Powder cultivated in vitro on the central nervous system of mice

作　　者：陆锦遥 王琼[1] 王优杰[1] 谷颖敏[1] 章鑫 谢家骏[1] 张小利 田雪松[1] LU Jinyao;WANG Qiong;WANG Youjie;GU Yingmin;ZHANG Xin;XIE Jiajun;ZHANG Xiaoli;TIAN Xuesong(Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Kaibao Pharmaceutical Co.,Ltd.,Shanghai 201401,China)

机构地区：[1]上海中医药大学创新中药研究院,上海201203 [2]上海凯宝药业股份有限公司,上海201401

出　　处：《药学研究》2020年第6期317-319,330,共4页Journal of Pharmaceutical Research

基　　金：国家科技重大专项(No.2017ZX09309006);上海中医药大学预算内项目(No.2014YSN24)。

摘　　要：目的观察体外培育熊胆粉对小鼠中枢神经系统的影响.方法小鼠分别灌胃低(0.8 g·kg^-1)、中(2.5 g·kg^-1)和高(8.0 g·kg^-1)剂量的体外培育熊胆粉,观察药物对小鼠一般行为和自发活动、协调运动及阈下睡眠剂量戊巴比妥钠协同作用的影响.结果在本实验条件下,给予体外培育熊胆粉后小鼠无异常行为,对自发活动及协调运动无明显影响,与阈下剂量的戊巴比妥钠无协同作用.结论在所设计的剂量水平下,体外培育熊胆粉对小鼠中枢神经系统未见明显影响.这些结果进一步扩展了我们对体外培育熊胆粉安全性的认识.Objective To observe the effects of Bear Bile Powder cultivated in vitro on the central nervous system of mice.Methods The changes in general behavior and spontaneous activity,coordinated movement,and hypnosis of subliminal sleep doses of pentobarbital sodium in mice were observed to evaluate the effects of the Bear Bile Powder cultivated in vitro at the low,medium and high dosage of 0.8,2.5 and 8.0 g·kg^-1 by oral administration.Results Under the conditions of this test,no abnormal general behavior of mice was observed after oral administration of Bear Bile Powder cultivated in vitro.The Bear Bile Powder cultivated in vitro had no influence on the spontaneous activity and coordinated movement,and showed no synergetic hypnotic effect on pentobarbital sodium of mice.Conclusion Bear Bile Powder cultivated in vitro had no significant effects at the experimental dosages on central nervous system of mice.These results further extend our understanding of the safety of Bear Bile Powder cultivated in vitro.

关 键 词：体外培育熊胆粉 一般药理学 中枢神经系统 小鼠 

分 类 号：R285.5[医药卫生—中药学]