放散式体外冲击波对神经肌肉接头影响的研究进展  

Advances in research on the effects of radial extracorporeal shock wave on neuromuscular junction

作　　者：陈禹彤 姚黎清[2] CHEN Yutong;YAO Liqing(Department of Neurology,Zhaotong Hospital of Traditional Chinese Medicine,Zhaotong 657000,China;Department of Rehabilitation Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昭通市中医医院神经内科,云南昭通657000 [2]昆明医科大学第二附属医院康复医学科,云南昆明650101

出　　处：《中国医学物理学杂志》2020年第6期754-757,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81760414);云南省科技厅重大专项(2018ZF016);2018年云南省卫生健康委云南省康复临床医学中心资助项目;昆明医科大学研究生创新基金(2018S034)。

摘　　要：神经肌肉接头(NMJ)是运动神经元轴突末梢和相应肌纤维间连接的效应位点,是动作电位产生的基础,而NMJ处的乙酰胆碱受体等物质对于动作电位传导具有重要意义。痉挛患者上运动神经元受损时,周围神经持续地通过NMJ向肌肉发放冲动,肌肉出现持续性收缩。研究显示放散式体外冲击波对NMJ有一定作用,可减少动作电位的产生,有助于痉挛的缓解,但冲击波在NMJ处的具体作用机制尚不完全明确,仍需进一步探明。Neuromuscular junction(NMJ)which is the effector site of the connection between the axon ends of motor neurons and the corresponding muscle fibers is the basis of action potential generation.Substances such as acetylcholine receptor at NMJ have important significance for action potential conduction.When the motor neurons in the patient with spasm are damaged,the peripheral nerve will continuously dole out impulses to muscles by NMJ,and the muscles will appear durative contraction.The research shows that radial extracorporeal shock wave has certain effect on NMJ,and that it can reduce the generation of action potentials,conducive to the relief of spasm.However,the specific mechanism of shock wave on NMJ remains unclear and needs to be further investigated.

关 键 词：放散式体外冲击波 神经肌肉接头 烟碱样乙酰胆碱受体 综述 

分 类 号：R318[医药卫生—生物医学工程]