ADD3基因rs17095355位点多态性与胆道闭锁相关性研究的Meta分析  

Meta-analysis of the relationship between single nucleotide polymorphism of rs17095355 and biliary atresia

作　　者：卫园园 范晋楠 李亚蕊[1] Wei Yuanyuan;Fan Jinnan;Li Yarui(Department of Pediatrics,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学儿科医学系,山西省太原市030001

出　　处：《临床小儿外科杂志》2020年第6期496-502,共7页Journal of Clinical Pediatric Surgery

基　　金：山西医科大学省级博士基金项目(编号:SD1828)。

摘　　要：目的采用Meta分析方法对rs17095355位点多态性与胆道闭锁相关性进行分析。方法纳入文献的发表时间截至2019年7月,检索英文数据库(PubMed、EMbase、Web of Science)及中文数据库(中国知网、万方数据知识服务平台、维普期刊资源整合服务平台和中国生物医学文献服务系统)中rs17095355位点基因多态性与胆道闭锁相关性的文献。采用Stata 14.0软件进行Meta分析。结果最终纳入7篇文献,共纳入8组独立样本的研究,共纳入6397人。Meta分析显示,rs17095355位点多态性与胆道闭锁患病风险相关,在等位基因、隐性基因、显性基因遗传模型下合并OR值及其95%CI分别为1.66(1.44~1.90)、1.66(1.38~2.01)和2.16(1.38~3.37),差异有统计学意义(P<0.05)。亚洲人群中等位基因遗传模型下该位点与胆道闭锁患病风险的合并OR值及其95%CI为1.72(1.48~1.99),差异有统计学意义(P<0.05)。按样本量大小进行亚组分析后,异质性减少。结论rs17095355位点多态性与胆道闭锁患病风险有关,特别是在亚洲人群中,T等位基因可能是发生胆道闭锁的危险因素,但该结论仍需不同种族中更多高质量、大样本的研究进一步证实。Objective To systematically evaluate the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and biliary atresia(BA).Methods The literature retrieval was conducted by searching the English databases(PubMed,EMbase&Web of Science)and Chinese databases(CNKI,Wanfang,VIP&SinoMed)for the publications on the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and BA by late July 2019.Meta-analysis was performed with software Stata 14.0.Results Seven reports and 8 independent studies were retrieved.Significant associations existed between higher risk of BA and single nucleotide polymorphism of rs17095355.The combined OR were 1.66(1.44-1.90)in allele,1.66(1.38-2.01)in dominant and 2.16(1.38-3.37)in recessive genetic model respectively(all P<0.05).The combined OR in allele genetic model was 1.72(1.48-1.99)in Asian populations(P<0.05).Sample size subgroup analysis showed lower heterogeneity.Conclusion There is significant association between BA and single nucleotide polymorphism of rs17095355,especially in Asian populations.T allele is a high-risk gene for BA.The results should be confirmed by larger high-quality samples from different ethnic groups.

关 键 词：胆道闭锁/病因学 META分析 基因 

分 类 号：R722[医药卫生—儿科] R575.7[医药卫生—临床医学]