鳞癌抗原检测在宫颈癌及癌前病变诊断的价值  

Diagnostic Value of Squamous Cell Carcinoma Antigen(SCC)Detection in Cervical Cancer and Precancerous Lesions

作　　者：方丹妹 FANG Danmei(Department of Obstetrics and Gynecology,Shantou Central Hospital,Shantou Guangdong 515000,China)

机构地区：[1]汕头市中心医院妇产科,广东汕头515000

出　　处：《中国卫生标准管理》2020年第11期35-37,共3页China Health Standard Management

摘　　要：目的探讨鳞癌抗原(squamous cell carcinoma,SCC)检测在宫颈癌及癌前病变诊断的价值。方法选取医院2018年1月9日-2019年12月27日入院被确诊为宫颈癌及癌前病变患者共339例,同时选取283例健康人群作为对照,A组为癌前病变患者、B组为宫颈癌患者、C组为健康人群,对比三组患者鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)水平以及阳性率。结果三组患者的数据进行对比,A组患者的SCC-Ag阳性率仅为8.70%,而B组患者的SCC-Ag阳性率65.08%,A组患者的阳性率明显低于B组,C组均为阴性,χ^2=234.844,P<0.05;B组患者的SCC-Ag水平(13.27±2.34)ng/mL高于A组患者SCC-Ag水平(0.96±0.22)ng/mL,A、B组两组患者的SCC-Ag水平均高于C组患者SCC-Ag(0.81±0.12)ng/mL,有统计学意义(F=7536.023,P<0.05)。结论鳞癌抗原(SCC)检测作为宫颈癌及癌前病变肿瘤标志物之一,可用于宫颈癌以及癌前病变诊断指标,有利于宫颈癌的早期诊断、早期治疗。Objective To explore the value of squamous cell carcinoma antigen(SCC)detection in the diagnosis of cervical cancer and precancerous lesions.Methods 339 patients with cervical cancer and precancerous lesions admitted to our hospital from January 9,2018 to December 27,2019 were selected.283 healthy people were selected as controls.Group A was precancerous lesion patients,Group B was cervical cancer patients,and Group C was healthy people.squamous cell carcinoma antigen(SCCAg)levels and positive rates of the three groups were compared.Results comparing the data of the three groups of patients,the positive rate of SCCAg in group a was only 8.70%,while the positive rate of SCC-Ag in group b was 65.08%.the positive rate in group a was significantly lower than that in group b,and all the patients in group c were negative χ^2=234.844,P<0.05.The SCC-Ag level of group b patients(13.27±2.34)ng/mL is higher than that of group a patients(0.96±0.22)ng/mL.the SCC-Ag level of group a and group b patients is higher than that of group c patients(0.81±0.12)ng/mL,with statistical significance(F=7536.023,P<0.05).Conclusion As one of the tumor markers of cervical cancer and precancerous lesions,squamous cell carcinoma antigen(SCC)detection can be used as a diagnostic indicator of cervical cancer and precancerous lesions,which is conducive to the early diagnosis and treatment of cervical cancer.The detection method is worthy of promotion.

关 键 词：鳞癌抗原(SCC)检测 宫颈癌 癌前病变 诊断 价值 阳性率 

分 类 号：R711[医药卫生—妇产科学]