未足月胎膜早破羊膜腔感染患者CRP、IL-6、 sPLA2、HBD-2变化及临床意义  被引量:16

Changes of CRP, IL-6, sPLA2 and HBD-2 in preterm premature rupture of membranes patients with amniotic cavity infection and their clinical significance

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作  者:马小莲 马振飞[2] 赵文斌[1] 尚鑫桐 詹进来 裘雅芬[1] MA Xiao-lian;MA Zhen-fei;ZHAO Wen-bin;SHANG Xin-tong;ZHAN Jin-lai;QIU Ya-fen(Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China)

机构地区:[1]杭州师范大学附属医院妇产科,浙江杭州310015 [2]丽水市遂昌县人民医院麻醉科,浙江丽水323300

出  处:《中华医院感染学杂志》2020年第9期1432-1435,共4页Chinese Journal of Nosocomiology

摘  要:目的探讨未足月胎膜早破羊膜腔感染患者CRP、IL-6、sPLA2、HBD-2变化及临床意义。方法选择2018年1月-12月杭州师范大学附属医院收治的胎膜早破孕妇52例为研究组,另选择同期在医院行孕期保健孕妇50名为对照组。比较两组孕妇入组时白细胞(white blood cell,WBC)、C-反应蛋白(C-reactive protein,CRP)、白细胞介素6(Interleukin-6,IL-6)、分泌型磷脂酶A2(secretory phospholipase A2,sPLA2)、β2防御素(β2 defensins,HBD-2)水平。研究组根据病理诊断结果分为羊膜腔感染亚组与无羊膜腔感染亚组,比较两亚组入组时、分娩时WBC、血清CRP、IL-6、sPLA2、HBD-2水平及保守治疗时间。结果入组时研究组CRP(8.1±2.2)mg/L、IL-6(10.5±3.3)pg/ml、sPLA2(126.8±33.6)ng/L、HBD-2(543.8±62.8)ng/L水平显著高于对照组(P<0.05),WBC水平比较差异无统计学意义。52例未足月胎膜早破孕妇妊娠结束时胎膜病理结果显示,18例发生羊膜腔感染,发生率为34.6%。羊膜腔感染亚组保守治疗时间(7.4±2.5)d,较非羊膜腔感染亚组保守治疗时间延长(P<0.05)。羊膜腔感染亚组与无羊膜腔感染亚组入组时WBC、CRP、IL-6、sPLA2、HBD-2水平比较差异无统计学意义,分娩时羊膜腔感染亚组上述指标水平显著高于无羊膜腔感染亚组(P<0.05)。结论未足月胎膜早破孕妇血清sPLA2、HBD-2水平显著高于未胎膜早破孕妇,发生羊膜腔感染的胎膜早破患者血清sPLA2、HBD-2水平升高显著,可用于辅助判断保胎治疗过程中是否羊膜腔感染,以及早预防,减少相关不良妊娠结局的发生。OBJECTIVE To explore the changes of CRP,IL-6,sPLA2 and HBD-2 in the preterm premature rupture of membranes patients with amniotic cavity infection and observe their clinical significance.METHODS Totally 52 pregnant women with premature rupture of membranes who were treated in the Affiliated Hospital of Hangzhou Normal University from Jan 2018 to Dec 2018 were chosen as the study group,meanwhile,50 pregnant women who received antenatal care in the hospital were set as the control group.The levels of white blood cell(WBC),C-reactive protein(CRP),interleukin-6(IL-6),secretory phospholipase A2(sPLA2)andβ2 defensins(HBD-2)were compared between the two groups of pregnant women at the enrollment.The patients of the study group were divided into the amniotic cavity infection subgroup and the non-amniotic cavity infection subgroup according to the result of pathological diagnosis,and the levels of WBC,serum CRP,IL-6,sPLA2 and HBD-2 as well as time of conservative treatment were compared between the two subgroups at the enrollment and at the time of delivery.RESULTS The levels of CRP,IL-6,sPLA2 and HBD-2 of the study group were respectively(8.1±2.2)mg/L,(10.5±3.3)pg/ml,(126.8±33.6)ng/L and(543.8±62.8)ng/L at the enrollment,significantly higher than those of the control group(P<0.05),there was no significant difference in the WBC level.The result of the pathological examination of fetal membranes that was carried out for the 52 pregnant women with preterm premature rupture of membranes at the end of delivery showed that 18 had amniotic cavity infection,with the incidence rate 34.6%.The time of conservative treatment of the amniotic cavity infection subgroup was(7.4±2.5)d,significantly longer than that of the non-amniotic cavity infection subgroup(P<0.05).There were no significant differences in the levels of WBC,CRP,IL-6,sPLA2 and HBD-2 between the amniotic cavity infection subgroup and the non-amniotic cavity infection subgroup at the enrollment,while the levels of above indexes of the amniotic cavity infection subgr

关 键 词:未足月胎膜早破 羊膜腔感染 分泌型磷脂酶A2 β2防御素 

分 类 号:R714.433[医药卫生—妇产科学]

 

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