O型血孕妇IgG抗A(B)效价与新生儿溶血病的关系分析  

Correlation between anti-A(B)titer of pregnant women with blood type O and neonatal hemolytic disease

作　　者：董艳 陈兆艳 汤传彦 DONG Yan;CHEN Zhaoyan;TANG Chuanyan(Department of Laboratory Medicine,the Maternal and Child Health Hospital of Rizhao City in Shandong Province,Rizhao 276800,China)

机构地区：[1]山东省日照市妇幼保健院检验科,山东日照276800

出　　处：《中国现代医生》2020年第13期151-153,157,共4页China Modern Doctor

摘　　要：目的分析O型血孕妇IgG抗A(B)效价与新生儿溶血病的关系。方法选取2018年9月~2019年10月我院收治的新生儿血型不合O型血孕妇198例,回顾其临床资料,分析O型血孕妇IgG抗A(B)效价与新生儿溶血病(HDN)的关系。结果孕1次者母体IgG效价≤1:128率(75.34%)较孕次≥2者(61.60%)高,年龄<30岁者Ig G效价≤1:128率(77.89%)较≥30岁者(59.22%)高,以上比较差异均有统计学意义(P<0.05)。母体IgG效价1:64、1:128、1:256、1:512情况下HDN发生率分别为2.56%、40.74%、45.65%、75.00%,母体IgG与新生儿HDN发生率呈正相关(r=0.827,P=0.000);不同效价组新生儿贫血发生率及严重程度、黄疸发生率及严重程度比较,差异不显著(P>0.05)。结论产前母体IgG效价与其新生儿HDN发生率呈正相关,对于效价高的孕妇加强观察并对其胎儿和新生儿加强观察,从而进行早期诊断和干预。Objective To analyze the relationship between IgG anti-A(B)titer of pregnant women with type O blood and neonatal hemolytic disease.Methods A total of 198 pregnant women with type O blood and incompatible newborn were selected from September 2018 to October 2019 in our hospital.The clinical data were reviewed,and the IgG anti-A(B)titer of pregnant women with type O blood and hemolytic disease of the newborn(HDN)were analyzed.Results The rate of maternal IgG titer≤1:128 in one pregnancy(75.34%)was higher than that in pregnancies≥2(61.60%).The rate of IgG titer≤1:128(77.89%)in patients<30 years was higher than that in patients≥30 years(59.22%),and the differences were statistically significant(P<0.05).The incidences of HDN in the cases of maternal IgG titers of 1:64,1:128,1:256,1:512 were 2.56%,40.74%,45.65%and 75.00%respectively.Maternal IgG was positively correlated with the incidence of neonatal HDN(r=0.827,P=0.000);there was no significant difference in the incidence and severity of neonatal anemia,and the incidence and severity of jaundice in different titer groups(P>0.05).Conclusion The prenatal maternal IgG titer is positively related to the incidence of HDN in newborns.For pregnant women with high titers,it is necessary to strengthen observation on their fetuses and newborns to conduct early diagnosis and intervention.

关 键 词：新生儿溶血病 ABO溶血 孕妇IgG抗A(B)效价 O型血孕妇 

分 类 号：R722.1[医药卫生—儿科]