阻塞性睡眠呼吸暂停低通气综合征对患者超声骨密度的影响及与跌倒风险的相关性  

Effect of obstructive sleep apnea-hypopnea syndrome on ultrasonic bone mineral density and its correlation with the fall risk

作　　者：黄占强[1] 王娜[1] 曹亚文[1] 赵翠[1] 曹俊杰[1] 巴春贺[1] 丁华杰[2] HUANG Zhanqiang;WANG Na;CAO Yawen;ZHAO Cui;CAO Junjie;BA Chunhe;DING Huajie(Department of Geriatrics,the Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Department of Ultrasonography,the Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院老年病科,河北承德067000 [2]承德医学院附属医院超声科,河北承德067000

出　　处：《大连医科大学学报》2020年第3期239-242,共4页Journal of Dalian Medical University

基　　金：承德市科技局项目(201701A046)。

摘　　要：目的观察不同程度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对患者超声骨密度的影响及与跌倒风险之间是否存在相关性。方法收集通过多导睡眠监测(PSG)确诊为OSAHS的患者65例,依据睡眠呼吸暂停低通气指数(apnea hypopnea index,AHI)分为轻中度组(44例)和重度组(21例)。选取经PSG排除OSAHS的同期住院患者31例为对照组。记录所有患者的一般资料,血Ca、血P、25(OHD)、PTH、骨密度T值及跌倒风险评分,比较各组间超声骨密度差异及与跌倒风险是否存在相关性。结果轻中度、重度组与对照组间骨密度差异无统计学意义(P>0.05)。AHI与血Ca、BMI呈正相关(P<0.05),AHI与骨密度T值呈负相关,对照组与轻中度OSAHS组跌倒风险差异无统计学意义(P>0.05),对照组、轻中度组与重度组OSAHS组跌倒风险差异有统计学意义(P<0.05)。结论OSAHS可能是超声骨密度减低的危险因素,导致跌倒风险增加。Objective To study the changes of ultrasonic bone mineral density(BMD)in patients with different degrees of obstructive sleep apnea-hypopnea syndrome(OSAHS)and its correlation with the risk of falls.Methods Sixty five patients with OSAHS diagnosed by polysomnography(PSG),were divided into mild/moderate OSAHS group(n=44)and severe OSAHS group(n=21).Thirty-one subjects without OSAHS confirmed by PSG,were included in control group.General information(age,sex,body mass index,and basic diseases),serum levels of calcium,phosphorus,25 hydroxyvitamin D and parathyroid hormone(PTH),T score and fall risk score were collected.The ultrasonic BMD and its correlation with fall risk were compared.Results There was no significant difference in the BMD between severe OSAHS group and mild/moderate group(P>0.05).AHI was positively correlated with body mass index and Ca(P<0.05),while negatively correlated with T score.There was no significant difference in the fall risk between control group and mild/moderate OSAHS group(P>0.05).Significant difference in the fall risk was detected when these two groups were compared to severe OSAHS group(P<0.05).Conclusion OSAHS may be a risk factor for decreased BMD and have increased risk of falls.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 超声骨密度 骨质疏松 跌倒风险 

分 类 号：R563.9[医药卫生—呼吸系统]