噻托溴铵联合布地奈德吸入剂对AECOPD病人胱抑素C、降钙素原及血气分析的影响  

Effect of tiotropium bromide combined with budesonide inhalation on the Cys-C,PCT and blood gas analysis in patients with AECOPD

作　　者：李子广[1] LI Zi-guang(Department of Respiratory Medicine,The Second Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233040,China)

机构地区：[1]蚌埠医学院第二附属医院呼吸内科,安徽蚌埠233040

出　　处：《蚌埠医学院学报》2020年第6期788-791,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨噻托溴铵吸入剂对慢性阻塞性肺疾病急性发作期(AECOPD)病人胱抑素C(Cys-C)、降钙素原(PCT)及血气分析的影响。方法:选取AECOPD病人120例,依照随机数字表法分为观察组和对照组,各60例。对照组予以布地奈德气雾剂治疗,观察组在此基础上联合噻托溴铵治疗。比较治疗前后肺功能指标、运动耐力、呼吸困难评分、Cys-C、PCT及血气分析的变化及不良反应的发生情况。结果:治疗后,2组病人各指标均升高(P<0.05~P<0.01),且观察组各项指标均高于对照组(P<0.05~P<0.01);治疗后,2组病人6 min步行试验得分均升高(P<0.05~P<0.01),且观察组高于对照组(P<0.01),2组病人呼吸困难评分均降低(P<0.01),且观察组低于对照组(P<0.01);治疗后,2组病人血清Cys-C、PCT均降低(P<0.01),且观察组各项指标均低于对照组(P<0.01);治疗后,2组病人SaO2、PaO2均升高(P<0.05~P<0.01),且观察组均高于对照组(P<0.01),而2组病人PaCO2均降低(P<0.01),且观察组低于对照组(P<0.01)。2组不良反应发生率差异无统计学意义(P>0.05)。结论:噻托溴铵联合布地奈德能够有效缓解AECOPD病人的炎症反应,降低血清Cys-C、PCT水平,改善呼吸功能,值得推广。Objective:To investigate the effects of tiotropium bromide combined with budesonide inhalation on the levels of cystatin C(Cys-C),procalcitonin(PCT),and blood gas analysis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:One hundred and twenty patients with AECOPD were randomly divided into the observation group and control group(60 cases in each group).The control group was treated with budesonide aerosol,and the observation group was treated with tiotropium bromide combined with budesonide.The exercise tolerance,lung function index,dyspnea score,Cys-C and PCT levels,blood gas analysis before and after treatment,and adverse reactions were compared between two groups.Results:After treatment,all indexes in two groups significantly increased(P<0.05 to P<0.01),and the indexes in observation group were significantly higher than those in control group(P<0.05 to P<0.01).After treatment,the scores of dyspnea in two groups significantly decreased(P<0.01),and which in observation group was lower than that in control group(P<0.01).After treatment,the serum levels of Cys-C and PCT in two groups decreased(P<0.01),and the indexes in observation group were lower than those in control group(P<0.01).After treatment,the levels of SaO2 and PaO2 in two groups increased(P<0.05 to P<0.01),and the indexes in observation group were higher than those in control group(P<0.01).After treatment,the level of PaCO2 in two groups decreased(P<0.01),and which in observation group was lower than that in control group(P<0.01).The difference of the incidence rate of complications between two groups was not statistically significant(P>0.05).Conclusions:Tiotropium bromide combined with budesonide can effectively alleviate the inflammatory reaction,reduce the levels of serum Cys-C and PCT,and improve respiratory function in patients with AECOPD,which is worthy of promotion.

关 键 词：慢性阻塞性肺疾病 噻托溴铵 胱抑素C 降钙素原 

分 类 号：R563[医药卫生—呼吸系统]