河南省2016-2018年HIV监测哨点人群的HIV-1新发感染检测和估算  

Test and Estimation of the HIV-1 Incidence Among Populations in HIV Sentinel Surveillance in Henan 2016-2018

作　　者：刘佳[1] 聂玉刚[1] 李宁[1] 田随安[1] 孙定勇[1] 王哲[1] LIU Jia;NIE Yugang;LI Ning;TIAN Suian;SUN Dingyong;WANG Zhe(Institute of STD and AIDS Prevention and Treatment,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China)

机构地区：[1]河南省疾病预防控制中心,性病艾滋病防治研究所,河南郑州450016

出　　处：《中国皮肤性病学杂志》2020年第7期796-799,共4页The Chinese Journal of Dermatovenereology

基　　金：国家“十三五”科技重大专项(2018ZX0715-009);河南省医学科技攻关计划项目(201702266)。

摘　　要：目的 了解2016-2018年河南省男男性行为者、性病门诊男性就诊者、孕产妇和女性性服务者人群的HIV新发感染情况。方法 收集2016-2018年河南省国家HIV监测哨点中四类人群的样本,使用限制性抗原亲和力酶免疫试验检测其中HIV-1抗体阳性的样本,估算新发感染率。结果 男男性行为者人群是这四个哨点中感染率最高的人群,其2016-2018年的感染率分别为7.53%、7.43%和5.74%,其新发感染率分别为:4.71%(2.97%~6.46%)、6.85%(4.87%~8.82%)和3.65%(2.25%~5.06%),三个年份间新发感染率的差异有统计学意义(χ2=7.27, P=0.03)。性病门诊男性就诊者人群是监测人数最多的人群,2016-2018年的监测人数分别达到3 162例、2 745例和3 161例,感染率分别为0.44%、0.77%和0.35%,其新发感染率分别为0、0.95%(0.12%~1.79%)和0.36%(0.35%~1.07%)。女性性服务者人群和孕产妇人群的感染率均低于性病门诊男性就诊者,女性性服务者人群三年的新发感染率为0.32%(0.30%~0.94%)、0和0.32%(0.30%~0.93%),孕产妇人群三年均未检测出新发感染的病例。结论 2016-2018年河南省男男性行为者人群的HIV新发感染率出现波动,其他人群HIV新发感染率低且平稳,哨点监测工作应不断完善。Objective To estimate the HIV-1 incidence of sentinel surveillance populations(men who have sex with man,female sex workers,pregnant women and male STD clinic attenders)in Henan 2016-2018.Methods Samples of the sentinel surveillance populations were collected in 2016-2018.Anti-HIV-1 positive samples were tested by Limiting Antigen Avidity Enzyme Immunoassay to identify the new-infected samples and the HIV-1 incidence was therefore estimated.Results The HIV prevalence of men who have sex with man was 7.53%,7.43% and 5.74% from 2016 to 2018,it was the highest prevalence among the four populations.The incidence of this population was 4.71%(2.97%~6.46%),6.85%(4.87%~8.82%)and 3.65%(2.25%~5.06%)from 2016 to 2018,and the difference was significant(χ2=7.27,P=0.03).3 162,2 745 and 3 161 cases were monitored among the male STD clinic attenders population from 2016 to 2018,with the HIV prevalence of 0.44%,0.77% and 0.35%,respectively,and the HIV incidence of this population was 0,0.95%(0.12%~1.79%)and 0.36%(0.35%~1.07%).The HIV prevalence of female sex workers and pregnant women were lower than male STD clinic attenders population,the incidence of female sex workers was 0.32%(0.30%~0.94%),0 and 0.32%(0.30%~0.93%)from 2016 to 2018,and there were no new infections were detected among pregnant women in any of the three years.Conclusion The HIV-1 incidence of men who have sex with man was fluctuant from 2016 to 2018,and other populations is low and stable.Sentinel surveillance should be improved constantly.

关 键 词：HIV-1 新发感染率 限制性抗原亲和力酶免疫试验 

分 类 号：R512.91[医药卫生—内科学]