脊髓损伤分子病理机制研究进展与思考  

Progress in and deliberation on molecular pathological mechanism of spinal cord injury

作　　者：程黎明[1] Cheng Liming(Department of Spine Surgery,Tongji Hospital Affiliated to Tongji University School of Medicine,Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration,Ministry of Education,Shanghai 200065,China)

机构地区：[1]同济大学附属同济医院脊柱外科,脊柱脊髓损伤再生修复教育部重点实验室,上海200065

出　　处：《中华创伤杂志》2020年第5期403-407,共5页Chinese Journal of Trauma

基　　金：国家重点研发计划(2016YFA0100800);国家自然科学基金国际(地区)合作与交流项目(81820108013);上海市重中之重重点学科建设计划(2017ZZ02004)。

摘　　要：脊髓损伤的病理过程复杂且病理机制尚未完整揭示,至今仍是一个医学难题。越来越多的学术观点认为不同程度、不同阶段的脊髓损伤有着独特的分子病理机制,即使是在相同的损伤类型情况下,患者个体遗传背景、基础疾病的差异也会影响脊髓损伤的程度和预后。全基因组测序技术通过对脊髓受损组织的表达谱测序分析,可以揭示脊髓损伤由急性期、亚急性期发展到慢性期的全部病理学机制动态发展过程,为精准干预脊髓损伤特定病理机制提供了重要理论基础。笔者就基因表达谱分析和基因表达调控及翻译后修饰方面对脊髓损伤病理机制的研究进行阐述,并对未来脊髓损伤分子病理机制研究需要解决的关键科学问题提出思考。Spinal cord injury is still an unsolved medical problem for which the pathological process of spinal cord injury is complex and its molecular pathological mechanism has not been fully revealed.More and more opinions show that spinal cord injury has a unique molecular pathological mechanism at different severities and different stages.Even in the same type of injury,the individual genetic background or personal chronic diseases may affect the severity and prognosis of the injury.The whole-genome sequencing technology can analyze the dynamic development process of all pathological mechanisms of spinal cord injury from acute phase,subacute phase to chronic phase through sequencing analysis of the expression profile of damaged spinal cord tissue,which provides an important theoretical basis for precision intervention of specific pathological mechanisms of spinal cord injury in the future.Herein,the author analyzes the mechanism of spinal cord injury through gene expression profiling,gene expression regulation and post-translational modification,explores the potential and promising therapeutic targets,and thinks over the key scientific issues that need to be solved in the molecular pathological research of spinal cord injury.

关 键 词：脊髓损伤 病理学 分子 基因表达谱 单细胞测序 

分 类 号：R651.2[医药卫生—外科学]