MoO3/SiO2催化合成咪唑并[1,2-a]吡啶衍生物  

Synthesis of Imidazole[1,2-a]Pyridine Derivatives Using MoO3/SiO2 Solid Acid Catalyst

作　　者：杨泽熙 马晓明[1] 刘建武[1] 严生虎[1] 张跃[1] YANG Ze-xi;MA Xiao-ming;LIU Jian-wu;YAN Sheng-hu;ZHANG Yue(School of pharmacy and Life Sciences,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164

出　　处：《化学试剂》2020年第6期709-715,共7页Chemical Reagents

摘　　要：研究了用负载型MoO3/SiO2固体酸催化Groebke-Blackburn-Bienaymé(GBB)三组分反应合成一系列咪唑并[1,2-a]吡啶衍生物。选用的反应底物为芳香醛、不同取代基的2-氨基吡啶以及TMSCN。主要考察了催化剂的负载量、底物物质的量比、反应温度以及反应时间对产物产率的影响。产物结构经红外、质谱、1HNMR和13CNMR表征,确定了咪唑并[1,2-a]吡啶衍生物合成的最佳温度为80℃、最佳反应时间为1 h、最佳反应底物物质的量比为1∶1.2∶1以及负载型MoO3/SiO2固体酸催化剂负载量为20 mol%时催化效果最好。负载型MoO3/SiO2固体酸催化剂具有催化活性高、反应条件温和的特点。A series of imidazole[1,2-a]pyridine derivatives were synthesized by the three component reaction of Groebke-Blackburn-Bienaymé(GBB)catalyzed by supported MoO3/SiO2 solid acid.Several aromatic aldehydes,2-aminopyridine with different substituents and TMSCN were selected as reaction substrates.The effects of catalyst loading,molar ratio of substrate,reaction temperature and reaction time on the yield of the products were investigated.The structures of the products were confirmed by IR,MS,1HNMR and 13CNMR.The optimum temperature,reaction time,molar ratio of substrate and supported MoO3/SiO2 solid acid catalyst were 80℃,1 h,1∶1.2∶1 and 20 mol%respectively.At last,it was concluded that the supported MoO3/SiO2 solid acid catalyst had high catalytic activity and mild reaction conditions.

关 键 词：MoO3/SiO2固体酸催化剂 Groebke-Blackburn-Bienaymé反应 咪唑并[1 2-a]吡啶衍生物 芳香醛 2-氨基吡啶 TMSCN 

分 类 号：TQ20[化学工程—有机化工]