噻托溴胺联合肺康复治疗稳定期慢性阻塞性肺疾病的疗效观察  

Observation on the Curative Effect of Tiotobromine Combined with Pulmonary Rehabilitation in the Treatment of Stable Chronic Obstructive Pulmonary Disease

作　　者：何观深 黄明珠 陈必桂 谭海涛 胡业焕 He Guanshen;Huang Mingzhu;Chen Bigui;Tan Haitao;Hu yehuan(Yangjiang people's Hospital of Guangdong Province,529500)

机构地区：[1]广东省阳江市人民医院,阳江529500

出　　处：《北方药学》2020年第6期58-59,共2页Journal of North Pharmacy

摘　　要：目的:探究噻托溴胺联合肺康复对稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法:选取我院呼吸内科于2018年1—12月收治的100例稳定期COPD患者作为研究对象,采用平行随机抽样法分为对照组与观察组,各50例。对照组给予噻托溴胺粉雾剂常规治疗,观察组在对照组基础上联合肺康复治疗,连续治疗10 d,对比两组的第1秒用力呼气容积(FEV1)、FEV占预计值百分比(FEV1%pred)以及用力肺活量(FVC),并随访3个月,对比两组的住院次数与发作次数。结果:①治疗后,观察组的FEV1、FEV1%pred以及FVC均明显优于对照组,差异具有统计学意义,P<0.05;②观察组的住院次数间、急性发作次数均明显低于对照组,差异有统计学意义,P<0.05。结论:在稳定期COPD常规药物治疗基础上开展肺康复治疗,能够明显改善肺功能,控制COPD发作次数,值得推广。Objective:To explore the clinical effect of tiotropium bromide combined with lung rehabilitation on stable chronic obstructive pulmonary disease(COPD),and to provide reference for the choice of treatment plan in the future.Methods:From January 2018 to December 2018,100 patients with stable COPD in respiratory department of our hospital were divided into control group(n =50) and observation group(n=50)by parallel random sampling.The control group was treated with thiobromine powder spray routine treatment,and the observation group was treated with lung rehabilitation treatment on the basis of the control group for 10 days.The percentage of forced breath volume(FEVl,FEV)to predicted value(FEV1%pred)and forced vital capacity(FVC)in the first second of the two groups were compared and followed up for three months.The number of hospitalization and seizures in the two groups were compared.Results:① after treatment,FEVl,FEV1%pred and FVC in the observation group were significantly better than those in the control group(P<0.05),and ②the number of acute seizures in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:On the basis of routine drug therapy in stable COPD patients,lung rehabilitation therapy can obviously improve the lung function of patients and control the number of COPD attacks,which is worth popularizing and applying.

关 键 词：噻托溴胺 慢性阻塞性肺疾病(COPD) 肺康复 疗效 

分 类 号：R563[医药卫生—呼吸系统]