补肾疏肝法对男性更年期综合征患者硫酸脱氢表雄酮的影响  

Effects of Bushen Shugan Recipe on dehydroepiandrosterone sulfate in patients with partial androgen deficiency of aging males

作　　者：廖敦 王益俊 陈凤兰 汤瑞珠 傅晓芸 李向芳 李轩 Liao Dun;Wang Yijun;Chen Fenglan;Tang Ruizhu;Fu Xiaoyun;Li Xiangfang;Li Xuan(Department of Traditional Chinese Medicine,Dongguan People’s Hospital Affiliated to Southern Medical University,Dongguan 523100,Guangdong,China)

机构地区：[1]南方医科大学附属东莞人民医院中医科,广东东莞523100

出　　处：《右江民族医学院学报》2020年第3期353-356,共4页Journal of Youjiang Medical University for Nationalities

基　　金：广东省中医药局资助项目(20181263);东莞市社会科技发展项目(2016105101018)。

摘　　要：目的通过观察补肾疏肝中药对男性更年期综合征(PADAM)患者血清硫酸脱氢表雄酮(DHEAS)的影响,探讨补肾疏肝法治疗PADAM的可能机制。方法选择符合纳入标准的110例PADAM患者,随机分为观察组和对照组,每组55例,观察组采用补肾疏肝法治疗,药用六味地黄汤合逍遥汤加减,每日1剂内服;对照组用雄激素补充疗法,予十一酸睾酮胶囊80毫克/次,2次/日,餐时口服,1个月后减为40毫克/次,2次/日;两组90 d为1个疗程。治疗前后统计患者PADAM评分,检测血清DHEAS、总睾酮(TT)、促卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E 2),并将结果进行对比分析。结果治疗后,两组患者体能+心血管症状、精神心理和性功能等评分均明显降低(P<0.05),且观察组PADAM评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清DHEAS、TT水平均升高(P<0.05),对照组血清TT水平明显升高(P<0.05),DHEAS水平变化不明显(P>0.05);治疗后观察组血清DHEAS水平高于对照组,差异有统计学意义(P<0.05)。结论补肾疏肝法可通过调整肾上腺-性腺轴内分泌活动,改善肾上腺、睾丸等器官自身分泌功能,提升PADAM患者血清DHEAS表达水平,改善患者临床症状,有效治疗PADAM。Objective To explore the possible mechanism of Bushen Shugan recipe in partial androgen deficiency of aging male(PADAM)by observing the effect of Bushen Shugan recipe of Chinese medicine on serum dehydroepiandrosterone sulfate(DHEAS)in patients with PADAM.Methods A total of 110 patients with PADAM were randomly divided into an observation group and a control group,each group included 55 cases.The observation group was treated with Bushen Shugan method using the combined drugs of Liuwei Dihuang decoction and Xiaoyao decoction by addition and subtraction,one oral dose daily.The control group was treated with testosterone undecanoate capsule for the supplement of androgens,80 mg once,twice daily,after one month the dose were subtracted to 40 mg once,twice daily,the therapeutic course for all patients was 90 days.Before and after treatment,the PADAM scores were recorded;the serum total DHEAS,total testosterone(TT),follicular stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E 2)were detected and the results were comparatively analyzed.Results After treatment,the scores of physical fitness plus cardiovascular symptom,mental psychology and sexual function were significantly reduced in the two groups(P<0.05),furthermore,the PADAM scores in observation group were lower than those in control group,the difference was statistically significant(P<0.05).After treatment,serum DHEAS and TT in observation group were increased significantly(P<0.05),and serum TT in control group was significantly increased(P<0.05),while serum DHEAS did not change significantly(P>0.05).After treatment,DHEAS was higher in observation group than those in control group,the differences were statistically significant(P<0.05).Conclusion Bushen Shugan recipe may improve the self endocrinologic functions of adrenal glands and testis organs by regulating the endocrinologic activity of adrenal gland-sexual gland axis,and can effectively increase the expressions of serum DHEAs in PADAM patients,and improve the patients’clinical symptoms,and effe

关 键 词：更年期综合征 男性更年期 补肾疏肝法 硫酸脱氢表雄酮 六味地黄汤/逍遥汤 

分 类 号：R588[医药卫生—内分泌]