心电图联合血清miR-1、CK-MB检测对早期急性心肌梗死的诊断价值  

Diagnostic value of ECG combined serum miR-1 and CK-MB detection for early acute myocardial infarction

作　　者：马珍珍 卢小伟 MA Zhen-zhen;LU Xiao-wei(Department of Cardiac Function,Affiliated Dongfeng Hospital of Hubei University of Medicine,Shiyan,Hubei,442000,China)

机构地区：[1]湖北医药学院附属东风医院心功能室,湖北十堰442000

出　　处：《心血管康复医学杂志》2020年第3期383-387,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探究心电图(ECG)联合血清微小RNA1(miR-1)、肌酸激酶同工酶(CK-MB)检测对早期急性心肌梗死(AMI)的诊断价值。方法:选择2016年3月至2017年6月本院的AMI患者65例为AMI组,另选择本院同期健康体检者50名为健康对照组。两组接受心电图检查,以及血清miR-1、CK-MB水平检测,分析比较两组的血清miR-1、CK-MB水平,分析二者的相关性,以及单独ECG、miR-1+CK-MB检测与三联检测对早期AMI的诊断效能。结果:与健康对照组比较,AMI组血清miR-1[(1.03±0.19)比(2.47±0.53)]和CK-MB[(6.72±1.24)U/L比(56.18±9.63)U/L]水平均显著升高,P均=0.001。Pearson相关分析显示血清miR-1水平与CK-MB水平呈显著正相关,r=0.578,P=0.001。血清miR-1+CK-MB检测的敏感度显著高于单独CK-MB检测(96.9%比76.9%),P=0.001。与单独ECG、miR-1+CK-MB检测比较,ECG+miR-1+CK-MB三联检测的敏感度(92.3%,96.9%比98.5%)、特异度(92.0%,86.0%比96.0%)升高;误诊率(8.0%,14.0%比4.0%)和漏诊率(7.7%,3.1%比1.5%)降低,但误诊率、漏诊率无显著差异,P均>0.05。结论:AMI患者的血清miR-1、CK-MB水平均显著高于健康对照组,血清miR-1+CK-MB检测对于急性心肌梗死的敏感度显著高于单独CK-MB检测。Objective:To explore diagnostic value of electrocardiogram(ECG)combined serum micro RNA1(miR-1)and creatine kinase isoenzyme MB(CK-MB)detection for early acute myocardial infarction(AMI).Methods:A total of 65 AMI patients treated in our hospital from Mar 2016 to Jun 2017 were regarded as AMI group,another 50 healthy subjects undergoing physical examination simultaneously were regarded as healthy control group.Both groups received ECG examination and detections of serum miR-1 and CK-MB levels.Serum miR-1 and CK-MB levels were compared between two groups,and their correlation well analyzed.Diagnostic efficacy of single ECG,miR-1+CK-MB and triple detection for early AMI were analyzed.Results:Compared with healthy control group,there were significant rise in serum levels of miR-1[(1.03±0.19)vs.(2.47±0.53)]and CK-MB[(6.72±1.24)U/L vs.(56.18±9.63)U/L]in AMI group,P=0.001 both.Pearson correlation analysis indicated that serum miR-1 level was significant positively correlated with CK-MB level,r=0.578,P=0.001.Sensitivity of serum miR-1+CK-MB detection was significantly higher than that of single CK-MB detection(96.9%vs.76.9%),P=0.001.Compared with single ECG and miR-1+CK-MB detection,there were rise in sensitivity(92.3%,96.9%vs.98.5%)and specificity(92.0%,86.0%vs.96.0%),and reductions in misdiagnosis rate(8.0%,14.0%vs.4.0%)and missed diagnosis rate(7.7%,3.1%vs.1.5%)in ECG+miR-1+CK-MB triple detection,but misdiagnosis rate,missed diagnosis rate without significant difference,P>0.05 all.Conclusion:Serum levels of miR-1 and CK-MB in AMI patients are significantly higher than those of healthy control group.Sensitivity of serum miR-1+CK-MB is significantly higher than that of alone CK-MB detection.

关 键 词：心肌梗死 心电描记术 微RNAS 

分 类 号：R542.22[医药卫生—心血管疾病]