DNA/银纳米簇介导的功能核酸生物传感器研究进展  

Research Progress on Functional Nucleic Acid Biosensors Mediated by DNA/Silver Nanoclusters

作　　者：杨敏 李舒婷[2] 杨文平 李相阳 许文涛 YANG Min;LI Shu-ting;YANG Wen-ping;LI Xiang-yang;XU Wen-tao(School of Food Science and Engineering,Beijing Agricultural College,Beijing 100083;Beijing Food Nutrition and Human Health Advanced Innovation Center,China Agricultural University,Beijing 100083)

机构地区：[1]北京农学院食品科学与工程学院,北京100083 [2]北京食品营养与人类健康高精尖创新中心中国农业大学,北京100083

出　　处：《生物技术通报》2020年第6期245-254,共10页Biotechnology Bulletin

基　　金：科技计划一般项目(KM201910020002)。

摘　　要：DNA/银纳米簇(DNA/Silver nanoclusters,DNA/Ag NCs)是以DNA为模板,NaBH4和银离子为反应物生成的一种新型荧光纳米材料。近年来,银纳米簇以其出色的光物理性质、良好的生物相容性、低成本、低毒性等优点成为了生物传感器设计及应用研究的一个热点。对DNA/银纳米簇介导的生物传感器的信号输出方式进行分类,并总结了DNA/Ag NCs在体内成像和抑菌方面的应用;最后,对DNA/Ag NCs介导的生物传感器目前存在的不足及今后的发展趋势进行了展望。DNA/Silver nanocluster(DNA/Ag NCs)is a novel fluorescent nanomaterial produced by using DNA as a template and NaBH4 and silver ions as reactants.In recent years,silver nanoclusters have become a hotspot in the design and applications of biological sensors due to their excellent photophysical properties,fine biocompatibility,low cost and low toxicity.The signal output methods in DNA/silver nanocluster-mediated biosensor are categorized,and the applications of DNA/Ag NCs in vivo imaging and bacteriostasis are also summarized.Finally,the shortcomings of DNA/Ag NCs-mediated biosensors and their future development trends are prospected.

关 键 词：荧光 银纳米簇 生物传感器 功能核酸 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置] O657.3[自动化与计算机技术—控制科学与工程]